Examples of 'hepcidin' in a sentence
Meaning of "hepcidin"
Hepcidin is a small peptide hormone that regulates iron metabolism by inhibiting the intestinal absorption and macrophage release of dietary iron. It is mainly produced in the liver and its levels are regulated by iron status, inflammation, and erythropoiesis
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- A hormone produced by the liver that regulates iron homeostasis in mammals.
How to use "hepcidin" in a sentence
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hepcidin
Several mutations in hepcidin result in juvenile hemochromatosis.
Hepcidin expression was lowered in a dose dependent manner.
Moreover alcohol reduces the production of hepcidin.
Hepcidin synthesis is mediated by physiological and pathological processes.
Hemojuvelin is probably a key modulator of hepcidin expression.
Hepcidin is a hormonal regulator of iron uptake in the intestine.
In patients undergoing hemodialysis there are elevated concentrations of hepcidin.
Hepcidin is involved in regulating iron homeostasis.
The erythropoyetic activity inhibit the release of hepcidin.
Hepcidin thus plays an important role in functional anaemia.
Inflammation would increase hepcidin expression.
Use of hepcidin as a regulator of iron homeostasis.
The overload of iron is associated with low levels of hepcidin.
Also hepcidin or adiponectin may be determined.
Any one of several mutations in hepcidin result in juvenile hemochromatosis.
See also
Hepcidin is a regulator of iron metabolism.
Adjusting the concentration of hepcidin.
Again liver hepcidin levels were measured as described above.
In vitro studies suggest an antimicrobial effect associated with hepcidin.
Hepcidin may also be involved in iron sequestration during inflammation.
The liver produces hepcidin.
Fc in mice affected hepcidin expression and iron metabolism was tested.
People with thalassemia should produce hepcidin at high levels.
The conversion of prohepcidin to hepcidin is mediated by the prohormone convertase furin.
In certain embodiments the second agent is an iron chelator or a hepcidin agonist.
Hepcidin ultimately breaks down the transporter protein in the lysosome.
Fc administration in mice does not affect hepcidin expression or iron metabolism.
Hepcidin measurement methods.
Mechanism of hepcidin action.
Natural hepcidin is difficult to synthesize and has unfavorable pharmacological properties.
Substantial progress has been made to elucidate the mechanism of action of hepcidin.
Hepcidin mRNA can be detected within exosomes from human serum.
Iron content and inflammation regulate hepcidin and ferroportin expression in mammals.
Hepcidin is a key regulator of the entry of iron into the circulation in mammals.
Studies in mice have demonstrated a role of hepcidin in control of normal iron homeostasis.
Use of hepcidin for preparing a medicament for treating disorders of iron homeostasis.
Erythroferrone is a hormone that regulates iron metabolism through its actions on hepcidin.
Closely related hepcidin sequences are found in vertebrates from fish to humans.
Compounds of the present invention reduced expression of hepcidin mRNA in mouse liver.
The quantification of hepcidin levels in a sample permits comparisons between data sets.
Erythroferrone was discovered in the search for a factor that suppresses hepcidin expression.
Correcting hepcidin and iron levels in these mice did not improve their anemia.
There is still no reliable information available on normal serum levels of mature hepcidin.
Hepcidin is a peptide hormone that is present in higher concentrations when body iron is replete.
The regulation of the iron level in this context is controlled or regulated by hepcidin.
Injection of hepcidin inhibits intestinal iron absorption in mice independent of their iron status.
The biological system may also preferably express hepcidin or comprise hepcidin.
Hepcidin controls intestinal iron absorption by regulating ferroportin expression on the basolateral membrane of enterocytes.
New medications that target the protein hepcidin are also being created and tested.
Its primary mode of action is the regulation of the iron storage hormone hepcidin.
