Examples of 'human constant' in a sentence
Meaning of "human constant"
human constant - a person who remains reliable, unchanged, or present in one's life
How to use "human constant" in a sentence
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human constant
The human constant region is denoted in italics.
The antibody may have human constant regions.
Human constant regions are known in the art.
It is composed of human constant and murine variable regions.
Thus the antibody may comprise a human constant region.
Analogues of human constant domains may alternatively be advantageously used.
Mouse variable region and human constant region.
Infliximab has human constant regions and murine variable regions.
Preferably such humanized version is chimerized with a human constant region.
It is comprised of human constant and murine variable regions.
Such variable regions can be combined with human constant regions.
Human constant region gene sequences are available in the form of publicly accessible deposits.
An antibody of the disclosure can also include a human constant region.
Human constant regions show allotypic variation and isoallotypic variation between different individuals.
The inventive human TCRs further comprise a human constant region.
See also
Preferred human constant light chain sequences include the kappa and lambda constant light chain sequences.
Thus the binding member may comprise a human constant region.
Why not have a human constant to go through it with?
An antibody of the invention can also include a human constant region.
A human constant region or portion thereof ;.
In one embodiment such humanized version is chimerized with a human constant region.
Human constant regions and murine variable regions e . g.
This molecule is a chimera composed of mouse variable regions coupled to human constant regions.
Other altered antibodies of the invention use human constant regions without such disabling mutations.
Chimeric antibodies can also comprise a murine variable region and a human constant region.
Most preferably IgG1 human constant region domains are used.
The cloned sequences are then combined with sequences encoding human constant regions.
The humanised antibody further comprises human constant heavy and light chain domains, where present.
Such variable domain sequences may then be combined with a desired human constant domain.
For example, a chimeric antibody may have a human constant region and a variable region from another species.
Primatized antibodies refer to antibodies comprising monkey variable regions and human constant regions.
In one embodiment, analogues of human constant domains may be used.
The construct encoded an antibody with the mouse variable region followed by a human constant region.
Preferred human constant light chain sequences ( CL ) include the kappa and lambda constant light sequences.
Chimeric antibodies comprising a mouse variable region and a human constant region are exemplary embodiments.
Preferably the human constant chain is IgG1 or IgG2 isotype.
The presence of a murine constant region can afford advantages over a human constant region.
Human constant regions include those derived from IgG1 and IgG4.
The antibody of the invention further comprises a human constant domain of the IgG isotype.
All of the murine and human constant region genes had been sequenced and published by 1989.
Any of the heavy chain variable regions may be combined with a suitable human constant region.
Such antibodies may further comprise a human constant region of the IgG isotype, e.g. IgG1.
A typical example of chimeric antibodies includes those comprising a murine variable region and a human constant region.
Old World Monkey, Ape etc and human constant region sequences.
Rituxan ® is an example of a chimeric antibody with a murine variable region and a human constant region.
In a more preferred embodiment, this human constant region is the human IgG1/Kappa constant region.
In some embodiments, the antibody includes a human constant region.
Restriction maps for the human constant regions are enclosed in Figure 21.
And a heavy chain constant region deriving from human IgG and a human constant light chain region.
Suitable human constant domain sequences can be obtained from Kabat et al . ( supra ).
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