Examples of 'human constant region' in a sentence
Meaning of "human constant region"
human constant region: Refers to a specific part of an antibody that is involved in binding to other immune system components
How to use "human constant region" in a sentence
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human constant region
The human constant region is denoted in italics.
Mouse variable region and human constant region.
Human constant region gene sequences are available in the form of publicly accessible deposits.
Thus the antibody may comprise a human constant region.
A human constant region or portion thereof ;.
Preferably such humanized version is chimerized with a human constant region.
Most preferably IgG1 human constant region domains are used.
An antibody of the disclosure can also include a human constant region.
In a more preferred embodiment, this human constant region is the human IgG1/Kappa constant region.
The inventive human TCRs further comprise a human constant region.
All of the murine and human constant region genes had been sequenced and published by 1989.
Thus the binding member may comprise a human constant region.
Comprises a human constant region that does not substantially bind human FcYIIIa receptor ( CD16 ) ; and.
An antibody of the invention can also include a human constant region.
For example, a chimeric antibody may have a human constant region and a variable region from another species.
See also
In one embodiment such humanized version is chimerized with a human constant region.
Such antibodies may further comprise a human constant region of the IgG isotype, e.g. IgG1.
Chimeric antibodies can also comprise a murine variable region and a human constant region.
Chimeric antibodies comprising a mouse variable region and a human constant region are exemplary embodiments.
The presence of a murine constant region can afford advantages over a human constant region.
Old World Monkey, Ape etc and human constant region sequences.
The construct encoded an antibody with the mouse variable region followed by a human constant region.
The humaneered Fab ' variants also comprised human constant region sequences.
A typical example of chimeric antibodies includes those comprising a murine variable region and a human constant region.
In some embodiments, a humanized antibody comprises at least one human constant region or fragment thereof.
Preferably, TACI-Fc comprises a heavy chain constant region of an immunoglobulin, more preferably a human constant region.
The antibody of claim 5 wherein the antibody comprises a human constant region of IgG isotype.
Chimeric antibodies are antibodies that include a non-human antibody variable region linked to a human constant region.
In a still further specific aspect, the human constant region is IgG1.
Any of the heavy chain variable regions may be combined with a suitable human constant region.
In one aspect, the constant region sequences are all human constant region sequences.
A humanized immunoglobulin does not encompass a chimeric antibody, having a mouse variable region and a human constant region.
Phosphorylatable chimeric antibodies with a mouse variable region and human constant region could be developed ( 93-99 ).
In one embodiment, the high affinity neutralizing antibodies of the invention include a human constant region.
In some embodiments, the antibody includes a human constant region.
Typically, the heavy chain constant region is human or a modified form of a human constant region.
SEQ ID NO, 5 and 6 Nucleotide and amino sequences of human constant region domain.
In another embodiment, an antibody of the invention comprises a human constant region.
In another embodiment, an antibody described herein comprises a human constant region.
An antibody as claimed in any preceding claim, further comprising a human constant region.
In an embodiment of the invention, the TCRs further comprise a human constant region.
In particular, said chimeric versions contain at least one human constant region.
In some embodiments, such humanized version is chimerized with a human constant region.
The method according to claim 8, wherein the constant region is a human constant region.
Like a chimeric antibody, a humanized antibody may contain a completely human constant region.
The antibodies or antigen binding fragments thereof, may have a human constant region.
Rituxan ® is an example of a chimeric antibody with a murine variable region and a human constant region.
Subsequently, the thus humanized, reconstructed human variable region is ligated to a human constant region.
Then, the humanized reshaped human variable region is ligated to the human constant region.
Chimeric antibodies combine a non-human animal variable region with a human constant region.
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