Examples of 'human heavy chain' in a sentence
Meaning of "human heavy chain"
human heavy chain - This phrase may refer to a series of interconnected human individuals with significant influence or power. It could describe a group of people who exert control or impact within a particular social, political, or organizational structure
How to use "human heavy chain" in a sentence
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human heavy chain
Construction of rearranged human heavy chain transgenes.
The human heavy chain locus is the largest and most diverse.
Preferably the heavy chain is a human heavy chain.
References of rearranged human heavy chain sequences used for alignment.
In some embodiments the heavy chain is a human heavy chain.
The sequences of human heavy chain constant region genes are known in the art.
This demonstrates antigen driven affinity maturation of the human heavy chain sequences.
Human heavy chain and light chain acceptor sequences are known in the art.
The two strains differ in the human heavy chain transgene used.
The following human heavy chain germline framework acceptor sequences can be used.
One such example is an antibody comprising murine light chain and human heavy chain polypeptides.
In one embodiment the human heavy chain constant region is a human IgG constant region.
Production of human Ig by chimeric mice Construction of human heavy chain replacement vector.
The KM mouse contains a human heavy chain transchromosome and a human kappa light chain transgene.
In a specific embodiment, the heavy chain is a human heavy chain.
See also
The constant region was primed from a human heavy chain sequence contained within a plasmid.
Human heavy chain constant region derived from IgG4.
VH amplification primers designed to amplify human heavy chain variable regions are contemplated.
In an aspect, the polyclonal antibodies further comprise a human heavy chain.
The ES cell may further comprise a human heavy chain locus and a human k light chain locus.
In a preferred embodiment, the polyclonal antibodies further comprise a human heavy chain.
Comprises a human heavy chain constant region ;.
In contrast, the transgenic strains are distinct with respect to their human heavy chain genes.
A preferred human heavy chain constant region is IgG3.
In some embodiments, the antibody comprises the human heavy chain IgG2a constant region.
In some cases, the human heavy chain constant region is modified for this purpose.
In more particular embodiments, the heavy chain variable domain is a human heavy chain variable domain.
L6 mice contain an inserted human heavy chain and an inserted human kappa light chain.
In one embodiment, the construct of the invention includes all human heavy chain D genes.
In one preferred embodiment, the human heavy chain constant region is a IgG4 constant region.
Use according to Claim 12, wherein the immunoglobulin moiety comprises a human heavy chain constant region.
Figure 15 is a repertoire analysis of human heavy chain transcripts expressed in XenoMouse II strains.
The human heavy chain J-µ intronic enhancer Hayday et al.
This is a schematic representation of the human heavy chain gene complex, not shown to scale.
Cloning human heavy chain variable region sequences from B cells from,.
Fig . 9 depicts the fragments used to construct a human heavy chain transgene of the invention.
The various human heavy chain Vectors differ only in the Fc-coding sequences.
The use of E 5, wherein the immunoglobulin moiety comprises a human heavy chain constant region.
A human heavy chain comprising,.
VH amplification primers designed to amplify human heavy chain variable regions are shown in Table 6.
YH2, the human heavy chain containing YAC, was further retrofitted with a human Y2 gene sequence.
PVg1 plasmid has a CMV promoter and contains the human heavy chain constant region of IgG1.
Frequently this human heavy chain framework 4 is of the sequence ' WGQGTLVTVSS '.
As described above, the vector includes human heavy chain D and J genes.
Heavy chain, A reshaped human heavy chain variable region gene was obtained by " de novo " synthesis.
The fusion protein of E 21, wherein the immunoglobulin moiety comprises a human heavy chain constant region.
SEQ ID NO, 24 is a human heavy chain constant region amino acid sequence.
The fusión protein of Claim 22, wherein the immunoglobulin moiety comprises a human heavy chain constant region.
SEQ ID NO, 25 is another human heavy chain constant region amino acid sequence.
Fig . 56 shows a schematic compilation of various human heavy chain and light chain transgenes.
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