Examples of 'human liver microsomes' in a sentence
Meaning of "human liver microsomes"
human liver microsomes: This phrase refers to subcellular fractions of liver cells that are commonly used in scientific research and drug metabolism studies. Human liver microsomes contain enzymes that play a crucial role in metabolizing drugs and other compounds in the body, making them valuable tools for studying drug interactions, toxicity, and efficacy
How to use "human liver microsomes" in a sentence
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human liver microsomes
Human liver microsomes were obtained from a commercial source.
Similar results were obtained using human liver microsomes.
Metabolic stability in human liver microsomes of compounds of this invention.
The metabolic stability was studied in human liver microsomes.
Glucuronidation in human liver microsomes like in rat liver microsomes is stereoselective.
Cucurbitacin e is hydrolyzed to cucurbitacin i in plasma and in human liver microsomes.
A sample of human liver microsomes is shown in track 5 for comparison.
Lapatinib did not significantly inhibit the following enzymes in human liver microsomes.
Human liver microsomes are diluted in assay buffer to a final assay concentration of 1 mg protein / mL.
Microsomes were obtained from the enterocytes as described for human liver microsomes.
Decreasing the concentration of human liver microsomes slows-down the metabolism of all test compounds.
All incubations were performed as described under incubations with human liver microsomes.
In vitro experiments with human liver microsomes ( HLMs ) indicate that darunavir primarily undergoes oxidative metabolism.
Furthermore the antibodies did not recognise any other protein in human liver microsomes.
In this Example, human liver microsomes form the biological medium.
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Assay for covalent binding between reactive metabolites and proteins using human liver microsomes.
The intrinsic clearance in rat or human liver microsomes is calculated from,.
For example, Streit et . al . structurally identified several rapamycin metabolites from human liver microsomes.
Results of metabolic stability study in human liver microsomes are given in Table 4.
Human liver microsomes or CYP2A6 microsomes were used.
Compound of formula I exhibited low clearance in human liver microsomes.
Compounds were incubated in human liver microsomes to estimate the disappearance t1/2 of the parent compound.
The stability of granaticin A was determined in mouse and human liver microsomes.
Pooled human liver microsomes are obtained from XenoTech LLC ( Kansas City, KS ).
In in vitro studies, daptomycin was not metabolised by human liver microsomes.
Human liver microsomes were utilized at a final concentration of 0.6 mg / ml.
A radiometric method to assay debrisoquine 4-hydroxylase activity in human liver microsomes was established.
In vitro studies using human liver microsomes and cDNA-expressed P450 enzymes have shown limited CYP3A4-mediated metabolism.
A probe substrate is introduced into a solution of human liver microsomes ( HLM ) which contains the enzymes.
Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.
The primary metabolic pathway of esketamine in human liver microsomes is N-demethylation to form noresketamine.
The recovery of radioactive material from HPLC column was 92.3 % for active human liver microsomes.
Lane 1 contains a sample of human liver microsomes for comparison ( 8 µg protein ).
And Fry J.R. Metabolism of coumarin by rat, gerbil, and human liver microsomes.
Formation of 6-B-hydroxytesosterone in human liver microsomes was inhibited 90 % at 1µM ketoconazole and ritonavir.
Human liver microsomes ( Lot FJM ) were obtained from Celsis ( Baltimore, MD ).
The compounds ( final concentration, 1 uM ) are incubated with human liver microsomes and NADPH.
Mixed gender pooled human liver microsomes were purchased from Tebu-bio ( Peterborough, U.K. ).
Drug Metabolism and Pharmacokinetics, Half-life in human liver microsomes ( HIM ).
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Examples of using Microsomes
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Hepatic microsomes were isolated from individual livers
Articaine is additionally metabolised in the liver microsomes
Microsomes and microparticles also can be used
