Examples of 'hydroxamate' in a sentence
Meaning of "hydroxamate"
hydroxamate (verb): the act of forming a chemical compound containing the hydroxamic acid group, often used in chelating agents in chemistry
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- A hydroxylamine compound containing a CONOH group, often serving as chelating agents.
How to use "hydroxamate" in a sentence
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hydroxamate
At such pH the hydroxamate will be present as a salt.
A stabilizer may comprise a hydroxamate chelant.
The expected hydroxamate product was in fact proved not to have formed.
Tlc indicated that all of the hydroxamate was consumed.
The hydroxamate composition is essentially free of water insoluble solvents such as fatty alcohols.
Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteinases.
Hydroxamate bond can be formed by reaction between an activated acid group and a hydroxylamine group.
Enzyme concentrations in the two supernatants were determined by the hydroxamate assay.
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase.
The sensitivity of the enzyme towards puromycin and leucine hydroxamate was also determined.
The hydroxamate compounds of the present invention can be produced by known organic synthesis methods.
Improvements in the industrial production and performance of the alkyl hydroxamate collectors are still required.
Scheme I also illustrates hydroxamate formation to prepare the hydroxamic acid products of this invention.
The flocculants may be any suitable flocculant, such as a polyacrylate or a hydroxamate.
There are several patents which disclose hydroxamate and carboxylate based MMP inhibitors.
See also
These hydroxamate compounds can be prepared by well-known methods.
A set of comparative formulations without hydroxamate was first made up as per table 13.
Hydroxamate derivatives of pyrene, porphyrin, phenanthroline and fluorescein chromophores were prepared.
The hydroxamic acid may be present as its corresponding alkali metal salt, or hydroxamate.
As examples of hydroxamate compounds, mention may be made of acetohydroxamic acid.
The reaction mixture is then warmed to room temperature to yield the desired hydroxamate 96.
The hydroxamate compounds are highly suitable for treating tumors, including cancerous tumors.
After filtration, the mixture was concentrated under reduced pressure to afford the crude hydroxamate.
Natchus et al describe development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines.
Example 3 This example examines the storage stability of the fatty hydroxamate of Example 1.
Novel hydroxamate derivative, a production method for the same, and a pharmaceutical composition comprising the same.
Table 1 Concentrations of surfactants and hydroxamate in wash liquors.
Alternately, hydroxamate compounds of the present invention can be prepared according to Scheme II.
Another preferred AQCA derivative is anthraquinyl-alanine hydroxamate shown in the following structure,.
It has a non-peptidic succinyl hydroxamate zinc binding group and a trimethylhydantoinylethyl group at the P1 position.
To 20 wt % hydroxamic acid or its corresponding hydroxamate of the structure.
Bright white foamy hydroxamate product material almost fully occupies the reactor space . Example 2a.
Reaction of the methyl ester 11 then affords the hydroxamate product 8.
It has a non-peptidic succinyl hydroxamate zinc binding group and a cyclic imide group at P1.
Hydroxamate compounds of the present invention can be prepared according to, for example, Scheme I.
The molecule has a typical diphenylboron hydroxamate structure featuring a five-membered COBON chelate ring.
This material is hydrogenated to give the final desired hydroxamate 118.
A procedure for making potassium alkyl hydroxamate is disclosed in Organic Synthesis, Vol.
A composition according to any preceding claim comprising at least 1 wt % alkyl hydroxamate ( d ).
For reviews of the patent literature on hydroxamate MMP inhibitors, see for example Beckett, Exp.
The infrared spectrum indicates conversion of 40 % of the amide groups to hydroxamate groups.
The 7-membered cyclic hydroxamate crystallizes in a chair conformation.
Example 4, Effect of concentration of hydroxamate.
Conversion of 47 to the hydroxamate 48 is conducted following the previously outlined procedures.
The crude product is purified by preparative HPLC to yield 30mg of hydroxamate 3c.
Example 8, Effect of hydroxamate on the cleaning performance of the composition.
Alternatively, the mixture of 4A and 4B was converted directly to its hydroxamate as described below.
Also disclosed are hydroxamate HDACi 's such as Suberoylanilide Hydroxamic Acid ( SAHA ).
Best results for both stability and cleaning are obtained with 1-6 % of hydroxamate.
This material is converted to the O-benzyl hydroxamate 115 vía a standard coupling reaction.
