Examples of 'immunoglobulin variable' in a sentence
Meaning of "immunoglobulin variable"
immunoglobulin variable: This phrase refers to a specific type of protein in the blood that plays a crucial role in the immune system's response to foreign substances
How to use "immunoglobulin variable" in a sentence
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immunoglobulin variable
Immunoglobulin variable region cassette exchange.
The preparation of single immunoglobulin variable domains is described below.
Immunoglobulin variable region.
The present invention relates to a modified immunoglobulin variable domain.
Single immunoglobulin variable domains are prepared in a number of ways.
Direct cDNA cloning of the rearranged immunoglobulin variable region.
The immunoglobulin variable gene segment is a human gene segment.
Immunocompetent phage can be constructed to express immunoglobulin variable region segments on their surface.
The immunoglobulin variable gene segment may be a human gene segment.
Also described are methods for making an effector light chain immunoglobulin variable domains.
Cloning immunoglobulin variable regions.
Each member comprises one polypeptide or nucleic acid sequence variant of an immunoglobulin variable region.
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.
The nucleic acid can correspond to a region encoding an immunoglobulin variable domain sequence described herein.
Cloning and sequencing of immunoglobulin variable region genes using degenerate oligodeoxyribonucleotides and polymerase chain reaction.
See also
This allowed for PCR amplification a majority of heavy chain immunoglobulin variable genes.
Blinatumomab consists of four immunoglobulin variable domains assembled into a single polypeptide chain.
That is, the binding site is provided by one, single immunoglobulin variable domain.
CDRs are the portions of an immunoglobulin variable region that interact primarily with an antigen.
In an embodiment, a multispecific antibody molecule comprises a third, fourth or fifth immunoglobulin variable domain.
Sequencing cloned genes Cloned immunoglobulin variable region genes were sequenced using a standard chain termination method.
Protein arrays of camelid heavy-chain immunoglobulin variable domains.
Generally, an immunoglobulin variable domain is selected for target specificity against a particular antigen.
In one embodiment, the promoter is a human immunoglobulin variable region gene segment promoter.
The immunoglobulin variable domain according to claim 1 or 2, which is humanized.
A polypeptide comprising at least one immunoglobulin variable domain according to any of claims 1 to 3.
These methods are less accurate, tending to underestimate the concentration of single immunoglobulin variable domains.
During B cell division the immunoglobulin variable region DNA is transcribed and translated.
For example, the reference sequence may be the length of the immunoglobulin variable domain sequence.
A heavy chain immunoglobulin variable region comprising,.
Immunological assays are generally suitable for the selection of target-specific immunoglobulin variable region encoding sequences.
A light chain immunoglobulin variable region comprising,.
Hypermutation is a part of the natural generation of immunoglobulin variable chain ( V ) genes.
In one embodiment, the immunoglobulin variable domain is a human Vλ or human Vk domain.
It has variable CD20 expression and unmutated immunoglobulin variable region genes.
In one aspect, the immunoglobulin variable domain is a human Vλ or human Vk domain.
According to one embodiment, all T cell epitopes are removed from the immunoglobulin variable domains.
In a specific embodiment, the immunoglobulin variable gene segment is a human gene segment.
The “ heavy chain variable region ” is also referred to as “ heavy chain immunoglobulin variable domain ”.
In a specific aspect, the immunoglobulin variable gene segment is a human gene segment.
Furthermore, the Fc-antigen or Fc-adjuvant fusión proteins lack an immunoglobulin variable region.
General techniques for cloning murine immunoglobulin variable domains are described Orlandi et al ., Proc.
An immunoglobulin variable region also consists of four “ framework ” regions surrounding the CDRs ( FR1-4 ).
In one instance, the promoter is a human immunoglobulin variable region gene segment promoter.
For reference to immunoglobulin variable regions, positions are numbered according to the Kabat numbering scheme.
Screening and engineering method of super-stable immunoglobulin variable domains and their uses.
The antibodies contain immunoglobulin variable region CDR sequences that define a binding site for human Notch3.
The sequences were aligned following AHo 's numbering system for immunoglobulin variable domain ( Honegger and Plückthun 2001 ).
The non-mouse immunoglobulin variable region sequences can be non-rearranged.
For example, the AHo numbering system for immunoglobulin variable domains may be used.
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