Examples of 'immunostimulatory nucleic' in a sentence
Meaning of "immunostimulatory nucleic"
The term 'immunostimulatory nucleic' refers to nucleic acids, such as DNA or RNA molecules, that have the ability to stimulate or activate the immune system. These nucleic acids can induce immune responses and enhance immune function. They are often used in research, medical treatments, or therapeutic approaches aimed at modulating the immune system's response to various diseases or conditions
How to use "immunostimulatory nucleic" in a sentence
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immunostimulatory nucleic
In some aspects the immunostimulatory nucleic acid is modified.
Immunostimulatory nucleic acids can be effective in any vertebrate.
Only certain nucleic acids are immunostimulatory nucleic acids.
Immunostimulatory nucleic acids can be produced on a large scale in plasmids.
In yet other embodiments the immunostimulatory nucleic acid has a chimeric backbone.
Immunostimulatory nucleic acid molecules have been implicated in the pathogenesis of arthritis.
Also according to preferred embodiments the immunostimulatory nucleic acid has a modified backbone.
The immunostimulatory nucleic acids are also useful as mucosal adjuvants.
The present disclosure provides various methods that involve immunostimulatory nucleic acids.
The immunostimulatory nucleic acids also induce maturation of dendritic cells.
The extent of phenotypic change induced by immunostimulatory nucleic acids differed from sample to sample.
The immunostimulatory nucleic acid useful in the kit is as described herein.
The term ISNA encompasses both synthetic and isolated immunostimulatory nucleic acids.
In some embodiments the immunostimulatory nucleic acid is an isolated nucleic acid.
The pharmaceutical composition of the present invention may further comprise immunostimulatory nucleic acid ( s ).
See also
immunostimulating
immunostimulatory
immunostimulatory nucleic acid
immunostimulatory oligonucleotides
immunostimulatory
immunostimulatory nucleic acid
immunostimulatory oligonucleotides
In some embodiments the immunostimulatory nucleic acid is administered by a mucosal route.
A use according to claim 52 wherein said immunostimulatory nucleic acid,.
In some embodiments the immunostimulatory nucleic acid is administered by a parenteral route.
An oligonucleotide as claimed in claim 1, wherein the immunostimulatory nucleic acid molecule,.
The immunostimulatory nucleic acid molecules may have a chimeric backbone.
In some embodiments, the immunostimulatory nucleic acid is modified.
Immunostimulatory nucleic acids.
Preferably, mixtures of different immunostimulatory nucleic acids are used in the present invention.
The immunostimulatory nucleic acid and other therapeutic agent may be administered simultaneously or sequentially.
In one embodiment, the lipid particle comprises an immunostimulatory nucleic acid or oligonucleotide.
Preferably the immunostimulatory nucleic acid is present in the composition in an effective amount.
Based on this finding, the invention features, in one aspect, novel immunostimulatory nucleic acid compositions.
In some embodiments the immunostimulatory nucleic acid is a synthetic nucleic acid.
Mice were subcutaneously primed with 20 µg p33-VLPs containing immunostimulatory nucleic acids.
The immunostimulatory nucleic acid molecules described herein have a variety of lengths.
Figure 26 shows ionic strength increases immunostimulatory nucleic acid packaging into QB VIPs.
The immunostimulatory nucleic acid molecules of the instant invention have chimeric backbone.
In a particular embodiment of the invention, the immunostimulatory nucleic acid sequence is a single-stranded RNA.
The immunostimulatory nucleic acids are useful as adjuvants for inducing a systemic immune response.
In other embodiments the Py-rich immunostimulatory nucleic acid is a C-rich nucleic acid.
The immunostimulatory nucleic acids and antibodies are useful for treating or preventing cancer in a subject.
The method described in paragraph 1, wherein the CpG immunostimulatory nucleic acid comprises a semi-soft backbone.
The immunostimulatory nucleic acids of the invention are also useful for treating these tumors.
In other embodiments, the immunostimulatory nucleic acid may be T-rich.
The immunostimulatory nucleic acid molecules of the present invention may have a chimeric backbone.
In other embodiments the immunostimulatory nucleic acid is 5 ' DCGHP 3 '.
The immunostimulatory nucleic acid molecules of the instant invention may include chimeric backbones.
In an embodiment the oligonucleotide comprising 5 ' Y1N1ZN2Y2 3 ' is administered separately from the immunostimulatory nucleic acid.
In other embodiments the immunostimulatory nucleic acid has a completely phosphodiester backbone.
The immunostimulatory nucleic acids are also useful for activating and inducing maturation of dendritic cells.
Of particular importance is the use of CpG immunostimulatory nucleic acids with interferon-a ( e.g., Intron A ).
Different immunostimulatory nucleic acids can cause optimal immune stimulation depending on the mammalian species.
In one embodiment, the immunostimulatory nucleic acid is a TG nucleic acid.
Immunostimulatory nucleic acid molecules comprising GTCGTT motifs.
In important embodiments, the CpG immunostimulatory nucleic acid is a C class immunostimulatory nucleic acid.
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Immunostimulatory oligonucleotides can be free of CpG dinucleotides
A muramyl dipeptide derivative is the immunostimulatory component
Examples of using Nucleic
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Both lipids and nucleic acids are degraded
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A virus is a string of nucleic acid with attitude
