Examples of 'inverse agonists' in a sentence
Meaning of "inverse agonists"
inverse agonists - substances that produce effects opposite to those of agonists in pharmacology
How to use "inverse agonists" in a sentence
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inverse agonists
Ligand gated ion channel inverse agonists.
Inverse agonists can inhibit this basal activity.
Known subfunctionalities are neutral antagonists or inverse agonists.
Benzodiazepine inverse agonists properties are indicated by the following tests.
Benzodiazepine receptor inverse agonists.
Inverse agonists act as antagonists to reverse the activity of agonists.
Compounds acting as inverse agonists can inhibit this activity.
Inverse agonists act to inhibit or reverse the activity of agonists.
The term includes partial agonists and inverse agonists.
Inverse agonists exert the opposite pharmacological effect of a receptor agonist.
Modulators that act as inverse agonists will reverse this effect.
This indicates that all these agents act as inverse agonists.
Use of ghrelin receptor inverse agonists or antagonists for treating sleep disorders.
Such compounds can inhibit the action of agonists or inverse agonists.
Inverse agonists and partial agonists may under certain assay conditions be antagonists.
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Such binding agents will preferably be used to screen for inverse agonists.
Inverse agonists bind to receptors and elicit the opposite effect that an agonist would.
The opioid antagonists naloxone and naltrexone are also partial inverse agonists at mu opioid receptors.
Inverse agonists reduce the activity of receptors by inhibiting their constitutive activity negative efficacy.
The present invention provides compounds that are useful as glucagon receptor antagonists or inverse agonists.
Conversely, inverse agonists are believed to stabilize an inactive receptor conformation.
RORY modulators include antagonists and inverse agonists of RORY.
Thus, retinoid inverse agonists may offer a unique way of treating diseases such as psoriasis.
G protein-coupled receptor inverse agonists.
Pain HT2A inverse agonists are also effective for the treatment of pain.
More particularly, it relates to glucagon antagonists or inverse agonists.
Inverse agonists decrease the signal ratio, and result in a negative % Effect value.
This is a list of opioids, opioid antagonists and inverse agonists.
GENFIT, Successful identification of RORγt inverse agonists as candidates for regulatory pre-IND studies.
In another aspect, the present invention provides compounds that are inverse agonists.
Inverse agonists at the H1 histamine receptor.
Representative examples of compounds that are inverse agonists include the following,.
Antihistamines, originally classified as antagonists of histamine H1 receptors have been reclassified as inverse agonists.
Histamine 4 receptor partial agonists, inverse agonists or antagonists for use in treating non-autoimmune uveitis.
This results in a receptor blockade, inhibiting the binding of agonists and inverse agonists.
Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases.
This increased basal activity ( constitutive activity ) can be inhibited by compounds called inverse agonists.
The compounds of formula I are antagonists and / or inverse agonists at the histamine 3 receptor ( H3 receptor ).
Inversago is developing new generations of CB1 receptor inverse agonists.
Compounds of Formula ( I ) are selective inverse agonists or antagonists for the CB-1 receptor.
The compounds of the invention are believed to be selective CB1 antagonists or inverse agonists.
Benzenesulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma ( RORY ( T ) ).
S1P and receptor agonists enhance the specific binding whereas inverse agonists reduce it.
Such agents or approaches include 5-HT1-7 receptors, GABA inverse agonists and other nicotinic acetylcholine receptors.
Consequently there are many potential therapeutic applications for histamine H3 agonists, antagonists, and inverse agonists.
More particularly, these compounds are selective antagonists or inverse agonists of the glucagon receptor.
As such modulators, the compounds may act as antagonists, agonists, or inverse agonists.
More particularly, these compounds are selective antagonists or inverse agonists of the histamine H3 receptor.
Direct-binding agonists can be further characterized as full agonists, partial agonists, inverse agonists.
Discriminative stimulus properties of beta-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors.
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Pleasure after all is the inverse of pain
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Examples of using Agonists
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