Examples of 'kinase domain' in a sentence
Meaning of "kinase domain"
In biology or biochemistry, a kinase domain refers to a specific region or part of a protein molecule that possesses kinase activity. Kinases are enzymes that catalyze the transfer of a phosphate group from ATP to another molecule, typically a protein, which can impact various cellular processes and signaling pathways
How to use "kinase domain" in a sentence
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kinase domain
Mutations in the epidermal growth factor receptor kinase domain.
They have a kinase domain that is similar to those of other isoforms.
Structural parts outside the core of the kinase domain were deleted.
The kinase domain of the enzyme was purified to homogeneity from a baculovirus expression system.
The remaining sequence comprises the intracellular tyrosine kinase domain.
Many of these receptors contain a tyrosine kinase domain in the intracellular region.
The cytoplasmic portion of the receptor comprises the tyrosine kinase domain.
Receptors often have a protein kinase domain in addition to the ligand recognizing domain.
This binding pocket is in the catalytic active site of the kinase domain.
Such analysis has identified a eukaryotic protein kinase domain for the kinases of the present invention.
Novel complex mutations in the epidermal growth factor receptor kinase domain.
Preferably a protein kinase domain mediates phosporylation by binding ATP.
It is this region which is known to bind to the kinase domain region receptor.
The tyrosine kinase Domain is highlighted by a dark shaded box.
Structural basis for activation of the titin kinase domain during myofibrillogenesis.
See also
The kinase domain is expressed in baculovirus and purified by the GST tag.
None of the clones shows an interaction with the kinase domain alone.
Enzymatic activity of the RTK kinase domain is essential for signal transduction.
The variant EGFR comprises at least one variance in its kinase domain.
DLK has a kinase domain and two putative leucine zipper motifs.
These peptides apparently act on the cytoplasmic kinase domain of the insulin receptor.
Tumor histology and EGFR kinase domain sequencing results were obtained from pathology reports.
Patients with activating mutations in the EGFR kinase domain more likely to respond.
AKT activation proceeds following a conformational change that dislodges the PH from the kinase domain.
The obligatory conserved amino acids within the kinase domain are labeled with asterisks.
These residue identity differences provide a basis for designing selective inhibitors of the BTK kinase domain.
Other cancer cell lines that harbor EGFR kinase domain mutations may be utilized.
The kinase domain falls into a family of that of calmodulin-dependent kinases.
The receptors comprise a heterologous extracellular domain and a kinase domain from an RRK protein.
In a similar way, the kinase domain may be engineered to improve kinase activity.
The mutant EGFR polypeptide can include a mutation in the kinase domain of EGFR.
The predicted kinase domain contains a kinase insert domain of approximately 71 amino acids.
In a particular instance the secondary EGFR mutation is an EGFR tyrosine kinase domain mutation.
Alternatively, mutations in the kinase domain that stabilize a kinase active conformation result in constitutive activation.
This membrane-bound protein has not an active kinase domain.
The fusión gene has a protein tyrosine kinase domain together with a coiled-coil domain.
Thereby, this insertion removes nearly the entire cytoplasmic kinase domain.
Also, small molecules targeted to the kinase domain have shown some success in the clinic.
Briefly, kinase activity is measured by incubating a fluorescent peptide substrate with the kinase domain.
It lacks an intracellular serine / threonine protein kinase domain and hence is a pseudoreceptor.
The ErbB3 membrane-bound protein has a neuregulin binding domain but not an active kinase domain.
Activate / stimulate the cytoplasmic kinase domain of the insulin receptor kinase or the insulin receptor kinase ;.
Modeling studies indicate that bosutinib binds the kinase domain of Bcr-Abl.
The kinase domain is located on the N-terminal.
These membrane-bound proteins possess an intracellular tyrosine kinase domain that interacts with various signaling pathways.
In some embodiments, the reagent specifically binds to an ALK kinase domain.
The cytoplasmic tyrosine kinase domain of the B-subunit is involved in signal transduction.
In some embodiments, the mutation is in the kinase domain of EGFR.
Nucleotide variances in the kinase domain are highlighted by patient number, see Table 2.
The sequences shown correspond to the C-terminal kinase domain.
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Examples of using Kinase
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Creatine kinase can be checked if myalgias develop
Blood tests show elevated creatine kinase
Elevation of creatine kinase in blood is indicative of myositis
