Examples of 'light chain variable region' in a sentence
Meaning of "light chain variable region"
In immunology, the light chain variable region is the part of an antibody that recognizes a specific antigen. It plays a crucial role in the immune response by binding to foreign substances
How to use "light chain variable region" in a sentence
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light chain variable region
Analyze the heavy chain and light chain variable region sequences.
The light chain variable region can be a humanized or human light chain variable region.
No donor framework residues were retained in the engineered light chain variable region.
The heavy and light chain variable region sequences are shown in the sequence listing.
The antibody contains a mature heavy chain or light chain variable region sequence.
The light chain variable region is separated from heavy chain variable region by a linker region.
This is done independently for both the heavy and light chain variable region sequences.
The light chain variable region is aligned with the variable region of the heavy chain.
The binding domain polypeptide can be a heavy chain variable region or a light chain variable region.
The antigen binding domain may comprise a light chain variable region and a heavy chain variable region.
Harvesting the immunoglobulin heavy chain variable region and the immunoglobulin light chain variable region.
The heavy and light chain variable region sequences from the Aximab hybridoma were determined.
Wherein the antibody comprises a light chain variable region comprising,.
A light chain variable region comprising the following CDRs,.
In some embodiments, the antibody further comprises an antibody light chain variable region.
See also
An antibody light chain variable region comprising,.
Nucleotide sequence of the gene for the humanized anti-Tac light chain variable region gene.
If a light chain variable region is linked to a constant region, preferably it is a k chain.
The antibody of claim 1, wherein said light chain variable region comprises the amino acid sequence.
If a light chain variable region is linked to a constant region, preferably it is a kappa chain.
The method may also comprise expressing a complementary light chain variable region ( or a complete light chain ).
Light chain variable region for Impilimumab,.
The heavy chain variable region and the light chain variable region each contain 3 CDRs.
The preferred light chain variable region is designated TF8LCDR3 and has the following sequence.
A polynucleotide encoding a heavy chain variable region and / or a light chain variable region of the antibody ; and.
In an embodiment, the light chain variable region is preceded by a signal peptide.
In one aspect, the non-human animal lacks a functional unrearranged immunoglobulin light chain variable region.
In various embodiments, the light chain variable region is capable of being somatically mutated.
SEQ ID NO, 2 corresponds to the amino acid sequences of the light chain variable region.
In an embodiment, the light chain variable region is linked to a k chain constant region.
FIGURE 3, shows a polynucleotide comprising a polynucleotide sequence encoding the light chain variable region of antibody E3.
In one instance, the light chain variable region comprises one to five somatic mutations.
In one aspect, the substitution ( s ) is in the immunoglobulin light chain variable region.
In one aspect, the human light chain variable region is a human Vk region.
The present invention also provides anti-IL-6 receptor antibodies comprising such light chain variable region.
RACE was performed for the light chain variable region with gene-specific primers.
In certain instances, the light chain CDR ( s ) are contained within a light chain variable region.
To construct the FR-patched light chain variable region sequence SEQ ID no.
The fragments preferably comprise a heavy chain variable region ( VH ) and / or a light chain variable region ( VL ).
In contrast, the light chain variable region differs by 5 amino acids.
Figure 5, Sequence alignment of the light chain variable region.
In some embodiments, a light chain variable region also comprises an FR1 and / or an FR4.
SEQ ID NO, 10 corresponds to the nucleotide sequence of the light chain variable region.
In some embodiments, the human light chain variable region ( VI ) sequences are kappa gene sequences.
It carries DNA encoding humanized 5A8 kappa light chain variable region.
A light chain may comprise a light chain variable region ( VL ) and a light chain constant region ( CL ).
SEQ ID No 14 is the amino acid sequence of the rat light chain variable region.
A first and a second light chain variable region comprising SEQ ID NO, 12.
SEQ ID No 13 is that of DNA encoding for the rat light chain variable region.
A light chain variable region comprising the amino acid sequence of SEQ ID NO, 43.
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