Examples of 'maytansinoid' in a sentence
Meaning of "maytansinoid"
maytansinoid (adjective) - relating to a group of maytansine-based cytotoxic agents, often used in targeted cancer therapies
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- Any chemical derivative of maytansine.
How to use "maytansinoid" in a sentence
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maytansinoid
Process for preparing maytansinoid antibody conjugates.
All treatment doses were based on conjugated maytansinoid.
The conjugate comprises a maytansinoid as a cytotoxic agent.
Maytansinoids and maytansinoid analogs are among the preferred cytotoxic agents.
The cytotoxic agent can be a maytansinoid.
Preferably the maytansinoid is linked to a antibody through a disulfide bond.
The cytotoxic agent is a maytansinoid.
In one aspect the maytansinoid drug moiety has the following stereochemistry.
This is generally the case of conjugates including maytansinoid molecules.
The antibody and its maytansinoid conjugate display very similar biphasic clearance profiles.
The conjugate comprises a maytansinoid.
The diastereomeric maytansinoid esters are readily separated by preparative TLC on silica gel.
The antibody drug conjugate wherein the cytotoxic agent is a maytansinoid.
Maytansine and maytansinoids An antibody may be conjugated to one or more maytansinoid molecules.
Another object of the present invention is to provide novel maytansinoid esters.
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Detection of free maytansinoid with HPLC The free maytansinoid was determined using an HPLC method.
Antibodies full length or fragment may be conjugated to one or more maytansinoid molecules.
Preparation of maytansinoid antibody conjugates by a one-step process.
These authors developed antibody conjugates wherein the antibody is linked to a maytansinoid vía a disulfide linkage.
D is a maytansinoid or monomethylauristatin drug moiety ;.
In some embodiments, the immunoconjugate comprises a maytansinoid.
The method of 3 wherein the maytansinoid is maytansinol.
In some embodiments, the first cytotoxic agent is a maytansinoid.
The method of 3 wherein the maytansinoid is a maytansinol ester.
In the present disclosure, the therapeutic agent is a maytansinoid.
A process for preparing an antibody maytansinoid conjugate comprising the step of,.
In one embodiment, the toxic payload molecule is a maytansinoid.
Toxins such as calicheamicin or a maytansinoid and analogs or derivatives thereof, are preferable.
According to the invention, the immunoconjugate comprises a maytansinoid.
The method of 3 wherein the maytansinoid is maytansine.
In some instances, part of the linker is provided by the maytansinoid.
Thus, a maytansinoid modified as described herein preferably comprises a thiol group.
In one embodiment, the cytotoxic agent is a maytansinoid or an auristatin.
That way, one or more maytansinoid residues may be linked to an antibody molecule.
In one specific embodiment, the antibody in the composition is conjugated to a maytansinoid.
In all these experiments the maytansinoid derivative 7b was used for conjugation.
The antibody drug conjugate, wherein the drug moiety is a maytansinoid.
In order to link the maytansinoid to the cell binding agent, a linking group is used.
In one embodiment, an immunoconjugate comprises an antibody conjugated to one or more maytansinoid molecules.
The method of 3 wherein the antibody and maytansinoid are conjugated by a bispecific chemical linker.
A preferred cytotoxic agent is a toxin, preferably a small molecule toxin such as calicheamicin or a maytansinoid.
Suitable cytotoxic agents include, for example, maytansinoids and maytansinoid analogs.
In order to link the maytansinoid to a cell-binding agent, the maytansinoid must first be modified.
According to the present disclosure, a preferred maytansinoid has a free thiol group.
Maytansinoid conjugates of antibodies, antibody fragments, and other proteins are made in the same way.
The modified antibody was then reacted with maytansinoid 7b forming thioether links.
In order to link the maytansinoid to the cell-binding agent, the maytansinoid comprises a linking moiety.
Most preferably, the antibody is chemically coupled to the maytansinoid vía disulfide bonds.
The preferred conjugates contain maytansinoid compounds linked to an anti-integrin antibody by a disulfide linkage.
The thiopyridyl groups were then displaced by reaction with the maytansinoid 7b to produce a conjugate.
