Examples of 'maytansinoids' in a sentence
Meaning of "maytansinoids"
maytansinoids (noun): A group of cancer drugs that are used in targeted cancer therapies
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- plural of maytansinoid
How to use "maytansinoids" in a sentence
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maytansinoids
Maytansinoids and calicheamicins are particularly preferred.
Examples of suitable maytansinoids include maytansinol.
Maytansinoids are mitototic inhibitors that act by inhibiting tubulin polymerization.
Derivatives are known as maytansinoids.
Strains produce maytansinoids called ansamitocins in small amounts.
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents.
Examples of suitable maytansinoids include maytansinol and maytansinol analogues.
The invention also discloses a process for the synthesis of these novel maytansinoids.
Maytansinoids are mitotic inhibitors which act by inhibiting tubulin polymerization.
The preferred cytotoxic compounds are maytansinoids and preferred chemotherapeutic compounds are taxanes.
Maytansinoids are mitototic inhibitors which act by inhibiting tubulin polymerization.
In one aspect, the drugs are maytansine and maytansinoids.
Maytansinoids are highly cytotoxic drugs.
Suitable cytotoxic agents include, for example, maytansinoids and maytansinoid analogs.
Maytansinoids and maytansinoid analogs are among the preferred cytotoxic agents.
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Three different antibodies were used for conjugation vía disulfide links to thiol-containing maytansinoids.
Examples of suitable maytansinoids include maytansinol and maytansinol analogs.
Reduction of the disulfide group with dithiothreitol gave the thiol-containing maytansinoids.
Examples of suitable maytansinoids include esters of maytansinol and maytansinol analogs.
In certain embodiments, cytotoxic agents useful in the present invention are maytansinoids and maytansinoid analogs.
These novel maytansinoids are suitable for use in the present disclosure.
Methods of conjugation of cell-binding agents with maytansinoids generally involve two reaction steps.
Maytansinoids arc mitototic inhibitors which act by inhibiting tubulin polymerization.
The compounds are useful for linking cytotoxic maytansinoids to cell-binding agents such as antibodies.
Maytansinoids are derivatives of maytansine.
The key raw material for preparing maytansinoids is maytansinol, which is obtained from ansamitocins hydrolysis.
Maytansinoids are compounds that inhibit microtubule formation and are highly toxic to mammalian cells.
In a second embodiment, the present invention discloses methods for the synthesis of these new maytansinoids.
Anticancer properties of maytansinoids have been attributed to their ability to disrupt microtubule function.
More specifically, the invention relates to novel cytotoxic agents comprising maytansinoids and their therapeutic use.
Maytansine and maytansinoids have been conjugated to antibodies specifically binding to tumor cell antigens.
FIG . 2 shows the structures of some of the maytansinoids of the present disclosure.
Many positions on maytansinoids can serve as the position to chemically link the linking moiety.
Schemes for preparing conjugates from sulfhydryl group-containing maytansinoids are shown in Figure 5.
Maytansine and maytansinoids An antibody may be conjugated to one or more maytansinoid molecules.
In another aspect, an immunocongugate comprises 8 maytansinoids per antibody.
In this regard, maytansinoids lack suitable functional groups to which antibodies can be linked.
In another aspect, an immunoconjugate comprises 8 maytansinoids per antibody.
Thiol-containing maytansinoids are not very soluble in the ethanol / water solvent mixture used for the reaction.
In one aspect, an immunoconjugate comprises about 1 to about 8 maytansinoids per antibody.
Maytansinoids and auristatins or bind DNA e . g.
The synthesis of thiol-containing maytansinoids useful in the present invention is fully disclosed in U. S.
In another aspect, an immunoconjugate comprises about 2 to about 7 maytansinoids per antibody.
The structures of various maytansinoids of the present invention are represented in Fig . 2.
Examples of toxins include, but are not limited to, radioisotopes, calicheamicin, and maytansinoids.
The maytansinoids are an example of a cytotoxin that can be conjugated with linkers attached at C-9.
Specific examples of suitable maytansinoids include, but are not limited to,.
Other cytotoxins include mycotoxins, ricin and its analogues, calicheamycins, doxirubicin and maytansinoids.
As used herein “ maytansinoids ” denotes maytansinoids and maytansinoid analogs.
FIG . 1 shows the structures of previously described maytansinoids.
