Examples of 'metalloprotease' in a sentence
Meaning of "metalloprotease"
Metalloprotease - a noun that refers to an enzyme that breaks down proteins and contains a metal ion in its structure
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- metalloproteinase
How to use "metalloprotease" in a sentence
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metalloprotease
These new compounds are new metalloprotease inhibitors.
A number of metalloprotease inhibitors have been described in the literature.
Zinc supplementation to increase responsiveness to metalloprotease therapy.
The metalloprotease secretion is detected and quantified by zymography.
The protease may be any acid fungal protease or metalloprotease.
The matrix metalloprotease is preferably a collagenase.
In an embodiment the protease is a metalloprotease.
Certain number of metalloprotease inhibitors have been described in the literature.
Compounds with related structures have been described as metalloprotease inhibitors.
Matrix metalloprotease participates in the maintenance of the extracellular matrix.
A suitable proteolytic enzyme for wound debridement is the metalloprotease collagenase.
Matrix metalloprotease inhibitors.
The hydroxamic acid group is a common motif in zinc metalloprotease inhibitors.
Suitable metalloprotease can be selected from the group of neutral metalloproteases and.
Polypeptides of the present invention are members of the metalloprotease family of polypeptides.
See also
Matrix metalloprotease inhibitors have been developed as a therapeutic agent for rheumatoid arthritis and osteoarthritis.
These results are also consistent with the autoproteolytic mechanism of metalloprotease activation.
Other conditions characterized by unwanted matrix metalloprotease activity include periodontal disease and epidermolysis bullosa.
The present invention also relates to inhibitors with differential metalloprotease activity.
Collagenase type IV is a pivotal metalloprotease enzyme involved in metastasis and cell invasión.
These compounds have the ability to inhibit at least one mammalian matrix metalloprotease.
Contacting said stem cells with said matrix metalloprotease or said active portion thereof.
These conjugates can be used as affinity reagents for the purification of a desired metalloprotease.
The gene sequence responsible for the production of metalloprotease may be inactivated or eliminated entirely.
Pancreatic islets are isolated from a pancreas by treating the pancreas with a collagenase and a neutral metalloprotease.
It can be also used as more highly purified neutral metalloprotease with high specific activity.
Proteases metalloprotease MMP and urokinase uPA are overexpressed in the tumor environment.
The present invention also relates to inhibitors with differential metalloprotease or reprolysin activity.
One such metalloprotease is Type IV collagenase.
Complete arrest of wound healing in plasminogen deficient mice treated with metalloprotease inhibitor.
Matrix metalloprotease inhibitors having the general formula, wherein.
The aforementioned authors reported that this enzyme was metalloprotease in the plasma and partially purified.
Additionally, the present invention relates to a method of producing the neutral metalloprotease.
TACE may be assayed using any of a variety of metalloprotease assays known in the art.
A polypeptide according to the above-described aspects of the invention functions as a metalloprotease.
The method of claim 1, wherein said matrix metalloprotease comprises collagenase.
One was identified as a calcium-dependent serine protease and the other a cysteine metalloprotease.
This enzyme belongs to the metalloprotease class, and it may be inhibited by phosphoramidon.
Such functional assays can directly indicate that a test agent modulates metalloprotease mediated myostatin activation.
Compounds having matrix metalloprotease inhibitory activity and the generalized formula, wherein.
That important task falls to a protein known as a matrix metalloprotease or MMP.
Luminescens tto1 stands out prta, a metalloprotease that belongs to the subfamily of serralysins.
The catalytic activity of HDAC contains features from both serine protease and metalloprotease enzymes.
Alternatively, besides a decrease in neutral metalloprotease level, it may be genetically altered in another respect.
Between the polyarginine sequence and the sequence of TRAIL sequences recognized by metalloprotease MMP SEQ.
The term " aggrecanase " as used herein means a metalloprotease exhibiting the aggrecanase activity.
It may be an alkaline protease, such as a serine protease or a metalloprotease.
This invention relates to compounds having matrix metalloprotease inhibitory activity according to claim 1.
Metalloprotease secretion is measured from treated primary human dermal fibroblasts, synoviocytes and chondrocytes.
Increased MMP expression after treatment with metalloprotease inhibitor.
