Examples of 'metalloproteases' in a sentence
Meaning of "metalloproteases"
Metalloproteases (noun): Enzymes that require a metal ion for their biological activity. Metalloproteases play a crucial role in various physiological processes, such as cell signaling and tissue remodeling
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- plural of metalloprotease
How to use "metalloproteases" in a sentence
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metalloproteases
Metalloproteases may be included in compositions of the invention.
These proteases are inhibited by specific inhibitors of metalloproteases.
Several metalloproteases are expressed during wound healing.
Aza spiro alkane derivatives as inhibitors of metalloproteases.
Many metalloproteases are highly expressed in tumor cells.
Such proteins are referred to as metalloproteases or MPs.
Metalloproteases have been isolated from a number of eukaryotic sources.
Preferable matrix metalloproteases include collagenase.
Metalloproteases have been isolated from a number of eucaryotic sources.
It is also an object of the invention to provide potent inhibitors of metalloproteases.
Neutral metalloproteases have been classified into two groups.
Ferroin is used as a cell permeable inhibitor for metalloproteases in cell biology.
It is already known that metalloproteases play an important role in the pathogenesis of acne.
They can be separated into the neutral and acid metalloproteases.
Inhibitors of metalloproteases are known.
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Some of the compounds of the invention also inhibit bacterial metalloproteases.
A significant increase of the metalloproteases activity creates an unbalance inducing a massive chondroresorption.
A number of small peptide like compounds which inhibit metalloproteases have been described.
Metalloproteases are characterized by the requirement of a divalent metal ion for their activity.
The uncontrolled breakdown of connective tissue by metalloproteases is a feature of many pathological conditions.
Suitable metalloprotease can be selected from the group of neutral metalloproteases and.
Pi class metalloproteases contain a pro domain and the catalytic domain in their structure.
These are high molecular weight protein molecules that form inactive complexes with metalloproteases.
Collagenases are zinc metalloproteases that cleave collagen and gelatin into small fragments.
Background of the Invention This invention relates to a tissue inhibitor of metalloproteases.
Several types of mammal cells secrete metalloproteases which are capable of degrading interstitial collagen.
Metalloproteases are a type of enzyme which degrade the extracellular matrix of the articular cartilage.
There are a number of structurally related metalloproteases which effect the breakdown of structural proteins.
Metalloproteases and Serine proteases are commonly found in the extracellular matrix.
The present inventors isolated and purified these neutral metalloproteases and demonstrated their enzymological properties.
The ECM metalloproteases are secreted as zymogens which undergo extracellular activation.
DETAILED DESCRIPTION The compounds of the present invention are inhibitors of mammalian metalloproteases.
Cleavage of chordin by these metalloproteases releases the BMP from the inhibitory effect of chordin.
New classes of ACE inhibitors are sought that will inhibit ACE and other zinc metalloproteases.
Activation of trophoblast-derived metalloproteases appears to be plasmin dependent.
A metalloproteases protease may for example be a thermolysin from e . g.
Suitable proteases include metalloproteases and / or serine proteases.
A further important class of proteases are the so-called metalloproteases.
Most metalloproteases require zinc, but some use cobalt.
Peptide hydrolases, such as subtilisins or metalloproteases.
Metalloproteases ( mps ) are proteins participating in several physiological and pathological processes.
A protein which is a tissue inhibitor of metalloproteases and characterized as follows,.
For example, linkers may be cleavable by such enzymes as metalloproteases.
Metalloproteases are in particular involved in the cicatrization process, eliminating the damaged tissues.
Figure 9 shows the family relationships of the various zinc metalloproteases.
A number of structurally related metalloproteases [ MPs ] effect the breakdown of structural proteins.
In accordance with the present invention, a novel tissue inhibitor of metalloproteases is provided.
Matrix metalloproteases degrade many types of extracellular matrix, which is one cause of articular destruction.
A number of smaller peptide-like compounds that inhibit metalloproteases have been described.
Suitable metalloproteases can include collagenases, hemorrhagic toxins from snake venoms and thermolysin from bacteria.
