Examples of 'minicells' in a sentence
Meaning of "minicells"
minicells (noun) - Refers to minicells, small spherical structures that are used in biology and biotechnology for the delivery of therapeutic agents or imaging agents. They are often employed in targeted drug delivery and cellular imaging. This phrase is used in the context of biotechnology, pharmacology, and medical research
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- plural of minicell
How to use "minicells" in a sentence
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minicells
The use of bacterial minicells in synthetic biology.
Minicells also may be formulated as a depot preparation.
Purification of minicells from bacterial species.
Minicells were purified by the following inventive method.
Three of the isolates revealed the presence of minicells.
Minicells of the invention contain one or more drugs.
Six isolates showed the presence of large numbers of minicells.
Such minicells may be used to deliver therapeutic agents.
Pharmaceutically compatible method for purifying intact bacterial minicells.
Minicells were purified via differential purifications.
The invention further provides methods of loading minicells with a drug.
Minicells returned to the first carboy vía the retentate line.
Primary ovarian cancer can be treated vía intraperitoneal delivery of targeted minicells.
Minicells are anucleated cells derived directly from parental bacterial cells.
Primary ovarian cancer may be treated vía intraperitoneal delivery of targeted minicells.
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The ability of minicells to package drugs is surprising for several reasons.
The invention further provides methodology for loading minicells with a drug.
Recombinant minicells can be purified from parent cells by several means.
Methods for determining the drug concentration in bacterially derived intact minicells.
Minicells can be incubated in this final medium for drug loading.
The results showed that the minicells were able to carry the siRNAs.
Minicells contain the same outer envelope as their parent bacterial cells.
Sucrose imparts a high osmolarity to gradients that can cause physiological changes in minicells.
Eubacterial minicells expressing immunogens from other prokaryotes have been described.
The invention also relates to a pharmaceutically compatible method for purifying intact bacterial minicells.
The ability of minicells to deliver drugs also is surprising for several reasons.
The discovery that drug movement occurs only in one direction in minicells was a greater surprise.
The minicells fluoresced bright green and were associated with the macrophages.
This example demonstrates a method for determining the concentration of a drug in bacterially derived intact minicells.
Eubacterial minicells are very well suited to serve as targeted delivery and imaging vectors.
Recombinant, intact bacterial minicells and.
The top segment contained largely minicells with contaminating bacterial cells and bacterial blebs.
Minicells of the invention are anucleate forms of E.
A catalase activity was also synthesized by the plasmid-containing minicells.
Control minicells that were not incubated with the drug did not show any background autofluorescence.
An additional flask was also included as a negative control, receiving no minicells.
Enumeration of minicells and bacterial cells was carried out by Flow Cytometry as follows.
Delivering functional nucleic acids to mammalian cells vía bacterially-derived, intact minicells.
Purity Minicells of the invention are substantially free from contaminating parent bacterial cells.
In a preferred embodiment of the invention, the intact minicells carry siRNA molecules.
Purification of minicells from bacterial species Minicells were purified by the following inventive method.
For example, overexpression of minE leads to polar division and production of minicells.
Intact minicells as vectors for DNA transfer and gene therapy in vitro and in vivo.
The researchers investigated the human immune response to the drug-loaded minicells.
The minicells were packaged with Doxorubicin.
This demonstrates the feasibility of in vitro gene therapy by means of recombinant, intact minicells.
Generation of minicells from Listeria monocytogenes.
The process was optimized and repeated more than 50 times to generate purified minicells.
First, large minicells introduce large delay variations.
Generally, filtration provides a sterile preparation of minicells suitable for gene transfer studies.
