Examples of 'misfolded proteins' in a sentence
Meaning of "misfolded proteins"
misfolded proteins: Misfolded proteins are biochemical compounds that have an abnormal or incorrect three-dimensional structure. This term is frequently used in biochemistry and molecular biology to describe protein folding errors that can lead to various diseases or malfunctioning in cellular processes
How to use "misfolded proteins" in a sentence
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misfolded proteins
This prevents the accumulation of misfolded proteins.
These misfolded proteins are called amyloids.
They are all experiencing the consequences of misfolded proteins.
The misfolded proteins are called prions.
An amyloid fibril is a large structure consisting of misfolded proteins.
Ironing out misfolded proteins.
Researchers identify crucial player in controlling misfolded proteins.
The ubiquitination of terminally misfolded proteins is caused by a cascade of enzymatic reactions.
Most neurodegenerative diseases are characterised by cellular accumulation of aberrant or misfolded proteins.
Chaperonin proteins may also tag misfolded proteins to be degraded.
Prions are misfolded proteins which replicate by converting their properly folded counterparts.
It was infected with misfolded proteins.
It was infected with misfolded proteins that have been spreading in their bodies ever since.
Neurodegenerative diseases are characterized by inclusions of misfolded proteins as one of the hallmarks.
These mutated or misfolded proteins therefore can not function normally.
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The strategy of cells to deal with the accumulation of misfolded proteins is identified.
Pharmacoperones can fix misfolded proteins and thus make them functional again.
Several neurodegenerative and other diseases are believed to result from the accumulation of misfolded proteins.
Study reveals how cells remove misfolded proteins from tissues.
This mass of misfolded proteins disrupts neuronal cell function and causes cell death.
Another line of cell defense against misfolded proteins is called the proteasome.
The technique could also prove useful in studying other diseases caused by misfolded proteins.
Amyloid plaques are aggregates of misfolded proteins that form in the spaces between nerve cells.
The proteasome is the molecular machinery responsible for removing damaged and misfolded proteins in cells.
Pathological features of the disease include misfolded proteins and accumulations in the central nervous system.
Misfolded proteins must be ubiquitinated to be sorted to the JUNQ.
However with aging and the decline of proteostasis misfolded proteins increase and lead to aggregation.
Misfolded proteins that are not ubiquitinated and terminally aggregated are sequestered to the IPOD.
Many systems within the ER are present for the detection of misfolded proteins.
Prion diseases are caused by misfolded proteins that replicate and eventually destroy the nervous system.
As we age, our cells accumulate damaged or misfolded proteins.
Identification of misfolded proteins associated with sporadic ALS through innovative proteomics approaches.
Hence, cellular viability depends on timely and efficient management of misfolded proteins.
A prime example is the synthesis of misfolded proteins like TTR that was previously not possible.
These misfolded proteins are disposed of via the endoplasmic reticulum associated glycoprotein degradation pathway ;.
Consequently, elaborate systems have evolved to protect cells from the deleterious effects of misfolded proteins.
An overwhelming load of misfolded proteins or simply the over-expression of proteins e . g.
Endoplasmic reticulum ( ER ) stress is a process of accumulation of misfolded proteins within the ER.
In most neurodegenerative diseases, misfolded proteins accumulate abnormally to form an insoluble clump called amyloid.
For instance, degenerative diseases like Alzheimer are caused by misfolded proteins.
Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD.
However, olive leaf extracts can prevent these misfolded proteins from entering the brain.
Misfolded proteins can be eliminated through the ubiquitin-proteasome system UPS.
Beauty and the Beast - when misfolded proteins cause havoc.
The ubiquitin proteasome system ( UPS ) functions in the removal of damaged or misfolded proteins.
In certain instances, misfolded proteins can accumulate in the ER before being eliminated.
Parkinson 's disease ( PD ) is a neurodegenerative disease associated with the accumulation and aggregation of misfolded proteins.
Sometimes, misfolded proteins form and this can lead to diseases such as Alzheimer 's disease.
Instead, the MRC team targeted the harmful way brain cells react to misfolded proteins.
In addition, misfolded proteins other than alpha-synuclein sometimes aggregate, or accumulate, in the same brains.
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