Examples of 'misfolding' in a sentence
Meaning of "misfolding"
misfolding (verb) - 'Misfolding' refers to the incorrect folding of proteins, leading to malfunctions and potentially causing diseases. It is a common phenomenon in biochemistry and molecular biology. Example: The misfolding of the protein was linked to the development of neurodegenerative disorders
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- present participle of misfold
- An incorrect folding (especially of a protein)
How to use "misfolding" in a sentence
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misfolding
The invention relates generally to protein misfolding.
Probably misfolding is also in general a kinetically controlled process.
An obvious path would be prevention of misfolding.
Caused by the misfolding of prion protein throughout the brain.
Cascade failure of the nervous system brought on by misfolding proteins.
Protein misfolding and aggregation are pathological aspects of numerous neurodegenerative diseases.
It was infected with misfolding proteins.
Chaperones mitigate this process by preventing or reversing protein misfolding.
Interplay of oxidative stress and protein misfolding in amyotrophic lateral sclerosis.
Molecular chaperones are a class of proteins that act by preventing aggregation and misfolding.
Additionally the effect of protein misfolding may be studied a kinetic manner.
Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding.
Quants are misfolding.
Compositions and uses for stabilising transthyretin and inhibiting transthyretin misfolding.
This event is likely to lead to a misfolding trajectory that results in protein aggregation.
See also
Compositions and method for stabilizing transthyretin and inhibiting transthyretin misfolding.
Recent research shows that protein misfolding happens frequently inside of cells.
Misfolding occurs either in the cell during fermentation or during the isolation procedure.
What distinguishes TSEs from other protein misfolding diseases is its transmissible nature.
Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases.
It was infected with misfolding proteins that have been spreading in their bodies ever since.
Neither is known much about the mechanism of the protein misfolding nor its kinetics.
OLIGOPEPTIDESProtein misfolding and altered cell communication.
This information will help comprehend what goes wrong in conditions associated with protein misfolding.
Recent research studies have demonstrated that protein misfolding often occurs inside of cells.
Protein misfolding and ER stress.
For the refolding process it is important to minimize the competing reactions misfolding and aggregation.
Inhibition of transthyretin misfolding in a tissue and / or within a cell is contemplated.
This method serves as a surrogate marker to identify compounds that should prevent TTR misfolding diseases.
MSS thus joins the group of protein misfolding and accumulation diseases.
Field of the Invention The invention relates generally to protein misfolding.
In some cases, misfolding of the protein results in a loss of its usual function.
Researchers in Switzerland and the United Kingdom have investigated protein misfolding using a sophisticated spectroscopic technique.
Taking advantage of inclusion bodies, this method is highly apt to induce misfolding.
Insulin is susceptible to fibrillation, a misfolding process leading to well ordered cross-B assembly.
Alzheimer 's disease has been identified as a protein misfolding.
Protein interactions include misfolding of proteins as well as protein-protein interactions such as aggregation.
To elucidate mechanisms of prion protein misfolding in TSEs 6.
Most protein misfolding diseases occur spontaneously at a specific stage of life, usually old age.
Consequently, he is focusing his research on diseases of protein misfolding that result in neurodegeneration.
Moreover, folding has important medical implications because most genetic defects cause protein misfolding.
The specification contemplates inhibition of transthyretin misfolding in a tissue and / or within a cell.
This method shows soluble aggregated protein, which is also indicative of protein misfolding.
Co-chaperones may also play an important role in misfolding diseases such as cystic fibrosis.
Abstract, Chaperonins are molecular machineries involved in the prevention of protein misfolding.
Aggregation is the result of misfolding such that the molecule irreversibly turns into a non-active state.
Huntington 's disease is a neurodegenerative genetic disorder that is associated with protein misfolding and aggregation.
Drugs targeting protein misfolding in glaucoma are summarized in Table 1.
Its exact cause remains unknown, but the disease is identified as a protein misfolding disease.
Misfolding of this protein leads to protein deposits that are the hallmark of Parkinson 's disease.
