Examples of 'modified bases' in a sentence
Meaning of "modified bases"
modified bases - In the context of biochemistry, this phrase typically refers to the altered forms of nucleotide bases found in DNA or RNA due to chemical modifications. These modifications can impact various cellular processes and gene expression
How to use "modified bases" in a sentence
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modified bases
The result is expressed in percentage of modified bases.
Particularly preferred modified bases are those that have been described above.
The sequences may also contain modified bases.
Modified bases could be incorporated partially or on the entire length of the oligonucleotide.
It is having a large number of modified bases.
The decoy polynucleotide may comprise modified bases or sugars to confer greater nuclease resistance.
Determination of percentage of modified bases.
Such modified bases provide additional binding interactions and increase the stability of aptamer secondary structures.
The polynucleotide may comprise modified bases or a modified backbone.
The nucleotides are selected from naturally occurring or synthetic modified bases.
The polynucleotide optionally comprises modified bases or a modified backbone.
Included are artificially modified nucleic acid molecules carrying chemically modified bases.
In particular formulas described herein modified bases may be incorporated.
Polynucleotide is also understood as meaning DNAs and RNAs containing one or more modified bases.
Stabilization can also involve using modified bases when synthesizing the mRNA constructs.
See also
This also includes nucleic acids containing modified bases.
The ODNs containing the modified bases in combination with MGB were hybridized to their complements.
In particular formulas described herein a set of modified bases is defined.
During the synthesis, modified bases can be incorporated internally or on its end.
No modifications or modified bases.
Modified bases and / or linker backbone chemistries may be desirable and functional in some cases.
Other enzymes can also be used to add modified bases or oligomers.
The traditional use of these modified bases in amplification primers is to reduce non-specific amplification.
The nucleic acid may also include native bases or modified bases.
Labelled oligonucleotides may contain modified bases such as phosphorothioate-modified bases.
The term also encompasses sequences having one or more modified bases.
However, outside of a palindromic sequence, modified bases may be used without this restriction.
Each of the above DNA glycosylases is specific for respective modified bases.
As discussed herein, certain modified bases can increase the stability of duplexes formed.
Synthetic antisense or triplex oligonucleotides may comprise modified bases or modified backbones.
The presence of modified bases may modify the fidelity of the HIV-1 reverse transcriptase.
Also provided are nucleosides and nucleotides containing modified bases of the present disclosure.
Incorporation of these modified bases increases the Tm about 3 °C per modification.
Polynucleotide also means DNA and RNA containing one or more modified bases.
Preferred modified bases are 5-substituted pyrimidines and 3-substituted pyrazolopyrimidines.
A ribozyme according to claims 1 to 7 characterized by one or more modified bases.
Such modified bases include for example 8-azaguanine and hypoxanthine.
In some embodiments, a polynucleotide oligomer comprises a plurality of modified bases.
The modified bases include inosine and the Non-Watson-Crick U-G basepair.
The aptamers can contain non-standard or modified bases.
MGBs and modified bases on " templates " inhibit extension by DNA polymerases.
In some embodiments, a polynucleotide oligomer comprises at least two modified bases.
MBs and modified bases on " templates " inhibit extension by DNA polymerases.
The nucleic acid ligands can contain non-standard or modified bases.
Endonuclease V recognises several modified bases in DNA including uracil, hypoxanthine ( inosine ) and urea residues.
Additionally, the nucleic acid may contain one or more modified bases.
Additional examples of modified bases and nucleotides are also described in, e.g., U.S. Pat.
Tritylated bases and special bases, such as inosine, are examples of modified bases.
For PCR, TAS, or 3SR, one can optionally incorporate modified bases into the primers.
In certain instances, glycosylase induction enhances lesion repair through increased excision of modified bases.
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