Examples of 'morpholino' in a sentence
Meaning of "morpholino"
Morpholino (noun): a type of molecule used in molecular biology to modify gene expression or function
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- A structural analog of natural nucleic acid used to modify gene expression, in which the ribose or deoxyribose rings of nucleic acids are replaced with morpholine rings and the phosphodiester intersubunit linkages of nucleic acids are replaced with phosphorodiamidate linkages.
How to use "morpholino" in a sentence
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morpholino
Morpholino substituted urea derivatives as mtor inhibitors.
Particularly preferred is a pyrrolidinyl group or a morpholino group.
Morpholino phosphorodiamidate oligomers morpholino oligonucleotides.
It is particularly preferably a methoxy group or morpholino group.
Morpholino antisense oligonucleotides are amply described in the literature.
Preferred heterocyclics include morpholino and piperidinyl.
Morpholino is the same as morpholinyl.
The heterocycle is preferably morpholino or pyrrolidinyl.
Antisense morpholino oligonucleotides AMOs are the same in mouse and human.
The antisense oligonucleotide comprises a morpholino.
Unsubstituted morpholino is particularly preferred.
More preferably the heterocyclyl group is morpholino or piperazino.
Coupling with the morpholino moiety then proceeds as outlined above.
Also preferred are oligonucleotides having morpholino backbone structures.
A claimed morpholino compound is preferably used in combination with an antimicrobial agent.
See also
Preferred heterocyclic rings include pyridine and morpholino.
A nucleic acid can comprise a morpholino backbone structure.
Phosphorodiamidate morpholino oligomers are modified backbone oligonucleotides that have previously been investigated as antisense agents.
The most preferred groups are morpholino and thiomorpholino.
Eukaryotic gene expression without intervention by a Morpholino.
Linking groups can link the morpholino monomeric units in a morpholino nucleic acid.
The heterocycle may be morpholino.
A variety of compounds within the morpholino class can be joined using different linking groups.
The amine may be provided by the amine of a morpholino group.
The entire backbone of a Morpholino is made from these modified subunits.
Examples of modified nucleic acids are PNAs and morpholino nucleic acids.
Such oligomers are composed of morpholino subunit structures of the form shown in Fig.
An antibiotic may therefore be used in a composition comprising a claimed morpholino compound.
An example of a phosphorodiamidate is Morpholino which is used in molecular biology.
Nucleic acid analogs included in the conjugates of the invention are morpholino oligomers.
Also are oligonucleotides having morpholino backbone structures Summerton and Weller.
An antisense structural type that has proven especially valuable in research is morpholino antisense.
The morpholino subunits can be prepared according to the following general Reaction Scheme I.
No shift was detectable for the morpholino and PNA AONs.
Preferably, the morpholino oligomers are fully uncharged.
We have synthesized short synthetic oligonucleotides of a type known as Morpholino oligos.
Most preferably, a morpholino phosphorodiamidate is used.
This effect however was not significant for the morpholino or PNA AONs.
Morpholino represents group with the following chemical structure,.
It is also preferred that Q represents a morpholino group.
The antisense morpholino oligomer according to claim 1, which is an oligonucleotide.
Preferably, the amino group is dimethylamino or morpholino.
In one embodiment, the subunits are morpholino subunits, and the linkages are phosphorodiamidate linkages.
In some embodiments, the heterocyclyl is morpholino.
The oligomer is preferably a morpholino oligomer, and is preferably contained in a pharmaceutically acceptable carrier.
In some embodiments, the oligonucleotide is a morpholino oligonucleotide.
The primary hydroxyl group of morpholino doxorubicin reacts with the chloroformate of the cross-linker.
Preferably, the heterocyclic group is for example pyridyl or morpholino.
An oligomer as recited in claim 8, which comprises morpholino subunits joined by phosphorodiamidate backbone linkages.
Preferably, the heterocycloalkyl is morpholino.
