Examples of 'morpholinyl' in a sentence
Meaning of "morpholinyl"
Morpholinyl (noun): Morpholinyl refers to the chemical functional group or moiety called morpholine, which consists of a six-membered ring containing an oxygen and nitrogen atom
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- A radical derived from morpholine
How to use "morpholinyl" in a sentence
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morpholinyl
Most preferably the heterocycloalkyl group is morpholinyl.
An unsubstituted morpholinyl group.
Preferred heterocycle groups are piperidinyl and morpholinyl.
The new morpholinyl anthracycline derivatives of the present invention are useful as antitumor agents.
In another embodiment the ring is a morpholinyl ring.
Pyrrolidinyl, piperidyl or morpholinyl or optionally substituted piperazinyl.
A particular example of the heterocyclic ring is a morpholinyl group.
The piperidinyl, morpholinyl or piperazinyl radicals are preferred.
Specific preferred rings include morpholinyl and piperidinyl.
Yet another embodiment is pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl.
Preferred is morpholinyl.
Examples of mono rings include piperidinyl, piperazinyl and morpholinyl.
Piperazinyl, piperidinyl and morpholinyl are preferred.
An example of a six membered cycloalkyl having O and N is morpholinyl.
Specifically, het is morpholinyl or thiomorpholinyl.
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Preferred heterocycles are piperidyl and morpholinyl.
The morpholinyl hemi-aminal metabolite is an unstable metabolite identified vÃa an iminium-ion trapping experiment.
A preferred group is the morpholinyl group.
Particularly preferred heterocycles are unsubstituted or substituted piperidinyl, pyrrolidinyl, piperazinyl, and morpholinyl.
Examples include tetrahydrofuranyl, morpholinyl and piperidyl.
Examples of such heterocyclyl groups include pyrrolidinyl, piperidinyl, piperazinyl and morpholinyl.
A compound of claim 22 wherein het is morpholinyl or thiomorpholinyl.
Preferable values under the scope of heterocycle include piperidinyl, pyrrolidinyl, and morpholinyl.
Examples of heterocyclyl are e.g. morpholinyl and piperidinyl.
In one embodiment of the present invention cycloheteroalkyl is selected from piperidinyl, pyrrolidinyl, and morpholinyl.
A more preferred combined preparation according to the invention comprises a morpholinyl anthracycline of formula ( I ) and cisplatin.
Morpholinyl having the formula,.
More preferably the heterocyclyl group is morpholinyl or piperazinyl.
Piperazinyl, piperidinyl, thiomorpholinyl, imidazolidinyl and morpholinyl groups are preferred.
The primary site of metabolism is the morpholinyl group.
For instance, the morpholinyl group may be substituted with two alkyl group, e.
Morpholino is the same as morpholinyl.
Specifically, piperazinyl group, morpholinyl group, pyrrolidinyl group, and piperidinyl group are more preferred.
The amide represented by Formula III contains at least one morpholinyl group.
Pyridinyl, pyrimidinyl, pyrrolidinyl, furyl, pyranyl, morpholinyl and thienyl are preferred heterocyclic groups.
Nitrogen-bound heterocyclyl such as piperazinyl or morpholinyl.
Is selected from hydrogen, morpholinyl or piperidinyl ;.
Another non-limiting example of heterocycloalkyl includes morpholinyl.
The heterocyclyl is selected from pyrazinyl, piperidinyl, morpholinyl, and pyrazolyl ; or the heterocyclyl is morpholinyl.
It can particularly be a pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl group.
More preferred heterocyclyl groups are tetrahydropyranyl, tetrahydrothiopyranyl, thiomorpholinyl, tetrahydrofuranyl, tetrahydrothienyl, piperidinyl, morpholinyl and pyrrolidinyl groups.
Examples of hetCyc1 include tetrahydropyranyl, piperidinyl and morpholinyl rings.
In one embodiment, morpholinyl comprises N-linked morpholinyl.
Preferred heterocyclyl groups are piperidinyl, morpholinyl and pyrrolidinyl.
Specific preferred rings include piperidinyl, methylpiperidinyl, dimethylpiperidinyl, hydroxymethylpiperidinyl, dichloropiperidinyl, hexamethyleneiminyl, and morpholinyl.
Examples of such non-aromatic heterocyclyl groups are morpholinyl or tetrahydro-pyranyl.
In one embodiment, monocyclic heterocyclyl includes pyrrolidinyl, tetrahydrofuranyl, dihydrofuranyl, pyrazolidinyl, oxazolidinyl, piperidinyl, piperazinyl and morpholinyl.
Examples of heterocyclic groups include piperidinyl, piperazinyl, morpholinyl and tetrahydrofuryl groups.
Non-limiting examples of suitable aromatic heterocyclyl groups include tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiopheneyl, pyrrolidinyl, piperidinyl, and morpholinyl.
Preferred IV-a groups include pyrrolidinyl, morpholinyl and piperidinyl.
