Examples of 'n-methylation' in a sentence
Meaning of "n-methylation"
n-methylation (noun): N-methylation is a chemical process in which a methyl group is added to a nitrogen atom
How to use "n-methylation" in a sentence
Basic
Advanced
n-methylation
N-methylation can affect a peptide in several ways.
The selectivity between O-methylation and N-methylation was not as high as would be expected.
Analogous N-methylation reactions were carried out on a variety of secondary amines.
The compounds of the present invention show little to no metabolic N-methylation in these assays.
N-Methylation had little effect on the rates of saponification of the charged forms.
Here also the option exists of N-methylation before cyclization or after cyclization.
Major biotransformations in the dog include hydroxylation, glucuronic acid conjugation and N-methylation in the liver.
Preferential axial attack was observed with N-methylation while N-phenacylation primarily proceeded by equatorial attack.
N-methylation of compounds LIII with methyl iodide XXXI, followed by hydrolysis gives compounds II.
Deiodination is followed by a one-pot N-methylation and reduction.
These results indicated that N-methylation with dimethyl carbonate is not applicable to such indole systems.
Alternatively, for methylation, an Eschweiler-Clark Reaction is utilized to achieve the desired N-methylation.
NNMT catalyzes the N-methylation of nicotinamide and other pyridines.
At this stage, the thiol-activated substrates can undergo modifications such as epimerisation or N-methylation.
N-methylation in the liver.
See also
This product may be also obtained by N-methylation of the compound already described in Example 14.
Table 1 records the effects of several electron-withdrawing functional groups on the N-methylation reaction.
For both enantiomers, N-methylation reduced rather than increased anti-HIV activity.
N-methylation in all other positions resulted in detectable, yet significantly reduced inhibitory activity ( Table 1-1 ).
The expected product is obtained by N-methylation of the compound of Example 34.
By reductive N-methylation of 9a-amino group according to Eschweiler-Clark process G.
Cleavage of the ribose and N-methylation yields 7-methylxanthosine.
