Examples of 'n-methylmorpholine' in a sentence
Meaning of "n-methylmorpholine"
n-methylmorpholine (noun): N-Methylmorpholine is a chemical compound commonly used as a catalyst in organic synthesis
How to use "n-methylmorpholine" in a sentence
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n-methylmorpholine
N-methylmorpholine was freshly distilled over sodium prior to use.
A base such as N-methylmorpholine may be added.
Preference is given to acetonitrile and N-methylmorpholine.
A N-Methylmorpholine salt develops and was filtered from mixture.
Suitable bases include triethylamine, N-methylmorpholine and particularly diisopropylethylamine.
In some cases, it is advantageous to add an amine base such as N-methylmorpholine.
Suitable bases include N-methylmorpholine or diisopropylethylamine, preferably diisopropylethylamine.
Alternatively, the polymerization can be conducted directly in triethylamine or N-methylmorpholine.
Preferred bases for this purpose are N-methylmorpholine and triethylamine.
The N-methylmorpholine salt is filtered off and washed with tetrahydrofuran.
A preferable base is triethylamine or N-methylmorpholine.
Preferred is N-methylmorpholine or pyridine and more preferred is N-methylmorpholine.
Under a nitrogen atmosphere, four equivalents of N-methylmorpholine is added to the stirred solution.
Cinnamoyl chloride was added immediately, followed by the other half of the N-methylmorpholine.
This procedure could also be done with N-methylmorpholine added to the reaction mixture.
See also
The ester formation is carried out in the presence of a tertiary amine such as N-methylmorpholine.
An excess of a tertiary amine such as N-ethyldiisopropylamine, N-methylmorpholine or triethylamine may optionally be included.
Bases typically used in these reactions are tertiary amines such as pyridine, triethylamine or N-methylmorpholine.
Other thioacetamide derivatives are obtained by employing N-methylmorpholine and a thioacetic acid in dimethylformamide ( DMF ).
In these cases the base is usually an organic amine, for example triethylamine or N-methylmorpholine.
Especially preferred are N-methylmorpholine and pyridine.
The ester formation is carried out in the present of a tertiary amine such as N-methylmorpholine.
N-Methylmorpholine was used instead of triethylamine.
One example of such a more soluble buffer is the salt of N-methylmorpholine with methanesulfonic acid.
Additional N-methylmorpholine N-oxide was added until the reaction had gone to completion.
A substance generally used for this purpose is the water solution of the N-oxide of N-methylmorpholine.
Add additional equivalents of N-methylmorpholine and TOTU and continue to stir for overnight.
Typical conditions include the use of BOP reagent and N-methylmorpholine.
N-methylmorpholine and the like.
This tertiary amine is preferably selected from N-methyl pyrrolidine or N-methylmorpholine.
N-methylmorpholine was added until the pH was 7.
Diisopropylethylamine, triethylamine and N-methylmorpholine are very suitable.
Alternately, N-methylmorpholine could be used in place of triethylamine.
Example 2 is repeated but using as a base N-methylmorpholine.
Among preferred bases, N-methylmorpholine or triethylamine may be mentioned.
In certain embodiments, the organic base is N-methylmorpholine.
Among these, N-methylmorpholine or triethylamine is preferable.
Typical bases are triethylamine, diisopropylethylamine, N-methylmorpholine or pyridine.
An organic base, such as N-methylmorpholine or diisopropylethylamine, may be added.
Advantageously, the base is triethylamine or N-methylmorpholine.
Preferably, N-methylmorpholine is used as base.
In advantageous embodiments, the base is a tertiary amine, particularly N-methylmorpholine.
Morpholine, HOBt, EDCI and N-Methylmorpholine were added again in the aforementioned ratios.
Most preferably, the base is ammonium hydroxide, triethylamine or N-methylmorpholine.
However, N-methylmorpholine N-oxide is apt to decompose due to the high temperature, generating coloring impurities.
In other embodiments, the organic base is triethylamine, diisopropylethylamine, N-methylmorpholine or pyridine.
Typically, the reclaimed N-methylmorpholine N-oxide solution is tinged with dark brown.
One or more of triethylamine, dimethyl cyclohexyl amine and N-methylmorpholine are preferred ;.
N-methylmorpholine or triethylamine ( 4 mmol ) was added and the mixture was sparged with nitrogen for 30 minutes.
A process according to claim 9, wherein the tertiary amine oxide is N-methylmorpholine N-oxide.
