Examples of 'nachr' in a sentence
Meaning of "nachr"
nachr (adjective): Nachr is a term that stands for "nicotinic acetylcholine receptor" in biology and pharmacology. It refers to a specific type of receptor protein involved in signal transduction processes related to neurotransmission and synaptic activity in the nervous system
How to use "nachr" in a sentence
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nachr
The usual neurotransmitter for nAChR is acetylcholine.
The nAChR receptor subtypes can be homopentameric or heteropentameric.
It acts as a competitive antagonist of the nicotinic acetylcholine receptor nAChR.
The nAChR is named for its affinity for nicotine.
Inhibition of monoamine uptake and nAChR function for hydroxybupropion analogs.
The nAChR site is indispensable.
The alpha subunit is a subunit of the NAChR to which ACh binds.
The nAChR contains two binding sites for snake venom neurotoxins.
Transfected cells are also analyzed to identify those that express NAChR protein.
The nAChR antagonist mecamylamine can be utilized in aerosol formulation to be administered vÃa inhalation.
The consortium investigated the contribution of different nAChR genetic elements to nicotine addiction.
A subgroup of that type is found only in neurons and is called the neuronal nAChR.
The consequence of this regulation is that ColQ controls nAChR clustering implicated in synaptic transmission.
The compounds are beneficial in therapeutic applications requiring a selective interaction at certain nAChR subtypes.
This method makes it possible to detect competitive nAChR agonists and antagonists with great sensitivity.
See also
Different nAChR ligands can stabilize the conformational state of a receptor to which they preferentially bind.
There exists a heterogeneous distribution of nAChR subtypes in both the central and peripheral nervous systems.
The different NAChR compositions exhibit different specificities for various ligands and are thereby pharmacologically distinguishable.
Nicotinic acetylcholine receptors antagonists Any of a variety of nAChR antagonists are known in the art.
All human nAChR subtypes analysed so far are sensitive to enhancement by API.
The inhibitory potency of pinnatoxin A depends on the nAChR subtype.
Many subtypes of the nAChR exist in the CNS and periphery.
NAChR refers to nicotinic acetylcholine receptor.
If currents are detected, the fragments are functional as NAChR.
Diverse nAChR subtypes are present in the CNS and PNS.
Recently, however, an interest in the development of nAChR modulators has emerged.
As noted above, nAChR responds to the agonist nicotine.
The compounds of the invention are selective for the a7 nAChR subtype.
Blockade of the a7 nAChR subtype induces a gating deficit similar to that seen in schizophrenia.
Thus, the compounds of the invention are found to be cholinergic ligands of the nAChR.
The nAChR antagonist mecamylamine may be administered with other anti-angiogenic agents.
In this assay, agents of the invention show selectivity for the a7 nAChR subtypes.
Sequence alignment shows that the alpha 7 nAChR is highly conserved during evolution.
In preferred embodiments, the compounds show selectivity for one or more nAChR subtypes.
The a7 nAChR is one receptor system that has proved to be a difficult target for testing.
In some cases, a gene other than those that make up the nAChR are involved.
Cholinergic system, particularly through a7 nAChR seems to have implications in traumatic brain injury-induced psychosis.
Certain nicotinic agonists are those that act a ligands at the a4B2 nAChR subtype.
Myasthenic autoimmune antibodies toward nAChR block the initiation of action potentials, mimicking an ACh-deficient state.
Antibodies Also provided herein are antibodies generated against the above-desribed nAChR subunits or portions thereof.
The opioids inhibited nAChR activation caused by nicotine without binding to the [3H]-epibatide binding site.
The resulting synthetic or recombinant receptor would contain the a6 and B3 nAChR subunits.
Inhibition of Neovascularization The a7 nAChR is also associated with neovascularization.
The inventors provide the genomic clones for mouse B-2 subunit of the neuronal nAChR.
Thus, schizophrenics express the same a7 nAChR as non-schizophrenics.
They are notable as ligands, especially agonists, at the a7 nAChR.
A7 nAChR agonists increase neurotransmitter release, and increase cognition, arousal, attention, learning and memory.
The subunits of the GABA ( A ) receptor have sequence homology with the nAChR subunit family.
A4B2 and a7 nAChR constitute the predominant subtypes expressed in the mammalian brain.
They are notable as ligands, especially agonists, on the a7 nAChR.
