Examples of 'nachrs' in a sentence
Meaning of "nachrs"
Nachrs - A noun that is unclear without context or further information
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nachrs
Sulfoxaflor binds to nAChRs in place of acetylcholine.
The nAChRs are activated endogenously by the neurotransmitter acetylcholine.
It functions as a ganglionic blocker of nicotinic acetylcholine receptors nAChRs.
Functionality of nAChRs was studied with calcium fluorometry.
These effects are caused primarily by activation of nicotinic acetylcholine receptors nAChRs.
Activation of nAChRs by nicotinic compounds results in neurotransmitter release.
Various autoimmune responses to muscle nAChRs can cause muscular paralysis.
The pharmacological and behavioral effects of nicotine involve the neuronal nAChRs.
Repeated exposure of nAChRs to nicotine leads to neuroadaptation to some of its effects.
High affinity nicotine binding sites may therefore be nAChRs in a desensitized conformation.
The nAChRs are excitatory and the often regulate the release of other neurotransmitters.
Acute nicotine directly acts on nAChRs and activates neural networks.
NAChRs also mediate the addictive effect of nicotine.
There are a decreased number of hippocampal nAChRs in postmortem brain tissue of schizophrenic patients.
Methods for identifying compounds which modulate the activity of NAChRs are also provided.
See also
NAChRs participate extensively in physiological functions and pathophysiological conditions.
Recent studies have also been reported that the nAChRs play a role in neurodegenerative disorders.
When nAChRs are activated there is a decrease in synaptic transmission of glutamate from CT neurons.
The other nicotinic compound is a compound that exhibits selectivity to nAChRs within the CNS.
DNA encoding nAChRs has been isolated from several sources.
These data indicate selectivity for CNS over PNS nAChRs.
NAChRs are part of the cholinergic system and its endogenous neurotransmitter is acetylcholine.
As ionotropic receptors, nAChRs are directly linked to ion channels.
The nAChRs are thought to be hetero-pentamers composed of homologous subunits.
Nicotine modulates multiple neuronal, peripheral and neuromuscular subtypes of nAChRs.
As used herein, nAChRs mean neuronal nicotinic acetylcholine receptors.
Some compounds may act as noncompetitive functional antagonists at the a4B2 nAChRs.
Nachrs are important to modulate the release of neurotransmitter such as dopamine, acetylcholine and glutamate.
Released acetylcholine interacts with nAChRs present on dopaminergic, as well as other striatal neurons.
Codeine, oxycodone and tramadol appear to affect as weak non-competitive antagonists of nAChRs.
Typically, nAChRs are ion channels that are constructed from a pentameric assembly of subunit proteins.
Upon interaction with a cholinergic agonist, muscle nicotinic nAChRs conduct sodium ions.
NAChRs of the latter type can selectively be labelled by the nicotine agonist 3H-cytisine.
For example, in some embodiments, the compounds may function as agonists by binding to nAChRs.
In addition, stimulation a-7 nAChRs can protect neurons against cytotoxicity associated with AB peptides.
Next, we observed that nicotine exposure induces accumulation of cAMP in cell cultures expressing nAChRs.
The activation of a7 nAChRs has been shown to block this neurotoxicity Kihara, T. et al ., J. Biol.
This toxin blocks in a quasi irreversible manner homomeric a7 nAChRs Palma et al.
In some embodiments, the compounds may be selective for a4B2 nAChRs.
The present thesis investigated the role of β4-containing ( β4 * ) nAChRs in nicotine addiction.
Further, it has been determined that AB peptides bind to a-7 nAChRs.
In particular, isolated DNA encoding human a7 subunits of neuronal NAChRs are provided.
Compounds of formula I are novel compounds which block the interaction of beta-amyloid with alpha-7 nAChRs.
An example of such a compound which binds to human alpha-7 nAChRs is a-bungarotoxin.
In particular, isolated DNA and RNA molecules encoding human a6 subunits of neuronal nAChRs are provided.
Specifically, isolated DNAs encoding human a4, a7, and B4 subunits of neuronal NAChRs are described herein.
