Examples of 'naloxegol' in a sentence
Meaning of "naloxegol"
Naloxegol is a drug used for the treatment of opioid-induced constipation in adults who are taking opioids for chronic non-cancer pain
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- A particular opioid receptor antagonist.
How to use "naloxegol" in a sentence
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naloxegol
It is unknown whether naloxegol is excreted in human milk.
Moventig contains the active substance naloxegol.
Naloxegol use is therefore not recommended during pregnancy.
Carcinogenicity studies of naloxegol were conducted in rats and mice.
Naloxegol to treat opioid induced constipation.
The active substance is naloxegol.
The use of naloxegol is not recommended in such patients.
Thus renal excretion is a minor clearance pathway for naloxegol.
The effect of naloxegol on fertility in humans has not been studied.
There are limited data from the use of naloxegol in pregnant women.
Naloxegol has not been studied in patients with severe hepatic impairment.
No data are available on the concomitant use of naloxegol with grapefruit juice.
The use of naloxegol in the paediatric population has not been studied.
Studies in suckling rats have shown that naloxegol is excreted in the milk.
Naloxegol at therapeutic doses has minimal uptake across the blood brain barrier.
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There is no gender effect on the PK of naloxegol.
The pharmacokinetics of naloxegol in the paediatric population has not been studied.
The blood brain barrier integrity is important for minimizing naloxegol uptake into the CNS.
Paediatric population The use of naloxegol in the paediatric population has not been studied.
Naloxegol is a PEGylated derivative of the mu-opioid receptor antagonist naloxone.
As a pure opioid antagonist Naloxegol has no potential for abuse.
Parent naloxegol excreted in the urine accounted for less than 6 % of the total administered dose.
Paediatric population The pharmacokinetics of naloxegol in the paediatric population has not been studied.
Therefore, naloxegol has not been studied in OIC patients with moderate or severe hepatic impairment.
Co-administration of boosted darunavir and naloxegol is contraindicated.
Doses of naloxegol up to 1,000 mg were administered in healthy volunteers in clinical studies.
If side effects impacting tolerability occur, naloxegol should be discontinued.
Chemically, naloxegol is a pegylated ( polyethylene glycol-modified ) derivative of α-naloxol.
Co-administration of Symtuza and naloxegol is contraindicated.
Food effects, A high-fat meal increased the extent and rate of naloxegol absorption.
In vitro studies demonstrate that naloxegol is a full neutral antagonist at the mu-opioid receptor.
Effect of severe hepatic impairment ( Child-Pugh Class C ) on the pharmacokinetics of naloxegol was not evaluated.
Each film-coated tablet contains naloxegol oxalate equivalent to 12.5 mg naloxegol.
Moventig 25 mg tablets naloxegol.
In clinical pharmacology studies, the half-life of naloxegol at therapeutic dose ranged from 6 - 11 hours.
Cases of opioid withdrawal syndrome have been reported in the naloxegol clinical programme DSM - 5.
Therefore, caution should be used when prescribing naloxegol to such patients see section 4.3.
Co-administration of boosted PREZISTA and naloxegol is contraindicated.
Co-administration of REZOLSTA and naloxegol is contraindicated.
Available toxicological data in rats have shown naloxegol excreted in milk see section 5.3.
Moventig 25 mg film-coated tablets Each film-coated tablet contains naloxegol oxalate equivalent to 25 mg naloxegol.
