Examples of 'oligomeric compound' in a sentence
Meaning of "oligomeric compound"
oligomeric compound: This phrase refers to a chemical compound composed of a small number of repeating units (monomers). Oligomeric compounds are larger than monomeric compounds but smaller than polymeric compounds
How to use "oligomeric compound" in a sentence
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oligomeric compound
The resulting oligomeric compound mediates physiological effects.
Chimeric antisense oligonucleotides are one form of oligomeric compound.
The linkages of such an oligomeric compound may be modified or unmodified.
Certain such modifications alter the activity of the oligomeric compound.
The nucleosides of such an oligomeric compound may be modified or unmodified.
This allows for selective chemistry to arrive at a desired compound or oligomeric compound.
Isolating the oligomeric compound.
Salts The Oligomeric compound can be employed in a variety of pharmaceutically acceptable salts.
Isolating the polymeric or oligomeric compound.
INA containing oligomeric compound are useful for a number of therapeutic applications as indicated above.
The molecular weight of the polymeric or oligomeric compound may vary.
In such embodiments, the oligomeric compound is complementary to a target nucleic acid.
Thus, the agent may be an antisense oligomeric compound.
In certain embodiments, an oligomeric compound consists of an oligonucleotide.
The term " motif " refers to the pattern of nucleosides in an oligomeric compound.
See also
In certain instances, an oligomeric compound consists of an oligonucleotide.
The target-binding domain constitutes the whole oligomeric compound.
In certain embodiments, an oligomeric compound comprises an oligonucleotide.
A preferred class of linking groups has been selected to give a non-ionic oligomeric compound.
In certain embodiments, an oligomeric compound is an oligonucleotide.
In the oligomeric compound of the invention, all nucleotide links are phosphorothioate groups.
Reacting the deprotected moiety of the oligomeric compound with the label.
In certain instances, an oligomeric compound further comprises one or more conjugate and / or terminal groups.
In certain embodiments, the bond for forming attachment to the oligomeric compound is a cleavable bond.
In the invention, the oligomeric compound comprises an oligonucleotide.
In another embodiment, T3 is an internucleoside linking group attached to an oligomeric compound.
In certain embodiments, such an oligomeric compound is a gapmer.
Preferably oligomeric compound according to the invention comprises two labels, preferably two fluorescent labels.
The activity is reduced for the modified oligomeric compound in the PTEN assay.
Thus, the length of the oligomeric compound includes any intermediate nucleotides where a nucleobase is absent.
Figure 2 Survivin mRNA downregulation by INA antisense oligomeric compound.
In certain embodiments, an oligomeric compound is a single-stranded oligonucleotide.
Oligomeric Compound 83e comprising a phosphodiester linked hexylamine was prepared using standard oligonucleotide synthesis procedures.
In certain embodiments, the oligomeric compound comprises a gapped oligomeric compound.
Figure 3A Survivin mRNA downregulation by INA antisense oligomeric compound.
In certain embodiments, an oligomeric compound is a double-stranded duplex comprising two oligonucleotides.
The process of claim 15, wherein the agent comprising said oligomeric compound is double-stranded.
The agent comprising an oligomeric compound may be single-stranded or double-stranded.
Growth rates ( AOD / h ) were plotted against the concentration of the oligomeric compound ( see Figures 4 and 5 ).
In certain embodiments, an oligomeric compound comprises one or more conjugate groups and / or terminal groups.
In particular, all nucleotide links in the oligomeric compound are phosphorothioate groups.
An oligomeric compound comprising at least one bicyclic nucleoside having Formula III,.
In one embodiment of the invention the oligomeric compound is linked to ligands / conjugates.
The oligomeric compound of embodiment 38 comprising a gapped oligomeric compound.
In certain such embodiments, the second oligomeric compound also comprises a conjugate.
An oligomeric compound of any one of claims 4 to 9 for use in medical therapy.
Preferably, the injectable solution doses of an oligomeric compound are pharmaceutical compositions as defined above.
The oligomeric compound of claim 16 wherein each internucleoside linking group is, independently, phosphodiester or phosphorothioate.
In certain embodiments, the second oligomeric compound is any modified or unmodified nucleic acid.
The oligomeric compound of claim 16 wherein each bicyclic nucleoside has Formula IV,.
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