Examples of 'ospa' in a sentence
Meaning of "ospa"
Ospa is a word that does not have a standard definition in English, it might be a name or a term in a specific context outside common English usage
How to use "ospa" in a sentence
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ospa
The OspA vaccine was tested for sterility.
A similar pattern of elution was obtained for OsPA.
Ten micrograms of OspA were used for each reaction.
The OspA vaccine induces a significant homologous antibody response.
A specific example of chimeric OspA is as follows.
The OspA fraction did not contain any adjuvant.
Immunogenicity of lipidated mutant OspA fragment heterodimers of different serotypes.
It has been shown that lipidation confers adjuvant properties on OspA.
These modified OspA molecules possess OspA antigenic activity.
These prothrombin activators are abbreviated as PtPA and OsPA respectively.
This method purifies OspA from an outer surface membrane preparation.
One such antigen is OspA.
Reactivity to OspA and OspB remained as the major antibody response detected.
In particular the antigen is OspA.
The safety of the OspA combination vaccine was also demonstrated by this study.
See also
A certain number of authors have noted variability of the OspA gene.
Such modified OspA molecules possess at least some OspA antigenic activity.
The same results were obtained with the OspA adjuvanted vaccine.
Preferred combinations include all or a portion of OspC linked to all or a portion of OspA.
One or more additional mutant OspA fragments may be present in the polypeptide.
The present invention is also drawn to a physiological composition comprising an altered OspA protein.
The genes encoding OspA and OspB are located on a double stranded linear plasmids.
These chimeric proteins have the general structure of OspC linked to OspA vÃa a peptide bond.
Manipulations of the OspA polypeptide sequence can be made at the protein level as well.
The chimeric polypeptides of the present invention elicit specific immune responses to OspC and OspA.
Nucleic acid encoding altered versions of OspA can be used to generate OspA chimeras.
The altered OspA polypeptides of the present invention also include larger fragments of OspA.
The first sixteen amino acid residues of OspA constitute a hydrophobic signal sequence of OspA.
Other OspA chimeras can be made using the same method with suitable primers.
Vanguard has developed a vaccine that combines chunks of seven different OspC proteins along with OspA.
Specific antibody to OspA was detected by an ELISA test.
These results demonstrate that vaccination with OspC may be more effective than vaccinations with OspA.
OspA was purified to homogeneity by exploiting its resistance to trypsin digestion.
Peptides and antigenic domains localized by fragmentation of OspA are summarized in Fig.
Accession numbers of OspA sequences from selected strains of Borrelia species.
The kit comprises an altered Borrelia burgdorferi OspA protein as described herein.
Dogs were tested for OspA antibodies at regular intervals by ELISA serology.
The leader sequence can have the Borrelia OspA leader sequence.
OspA antibody results have been determined for all of the dogs.
Polynucleotides encoding Borrelia burgdorferi OspA polypeptides can be selected as described herein.
The OspA polypeptide comprises portions of OspA from two or more strains of Borrelia.
An alignment of these and other OspA nucleic acid sequences is shown in Fig.
The PCR technique can be used in creating amino acid sequence variants of OspA.
OspB has a similar primary structure as OspA and is included in the following discussion.
Protection of mice against the Lyme disease agent by immunizing with recombinant OspA.
The OspA may be a full mature protein in a lipidated form virtue of the host cell E.
The Western blot analysis confirms that these new bands correspond to OspA derivatives.
OspA and OspC share many characteristics.
It has been speculated that the OspA protein of B.
In one embodiment, the altered OspA polypeptide of the invention is a chimeric polypeptide.
