Examples of 'ospemifene' in a sentence
Meaning of "ospemifene"
Ospemifene is a noun referring to a medication used to treat symptoms of menopause. It is primarily used in medical contexts
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- An oral medication used to treat dyspareunia.
How to use "ospemifene" in a sentence
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ospemifene
Ospemifene is not indicated for fertile women.
Senshio contains the active substance ospemifene.
Ospemifene was not teratogenic in rats or rabbits.
The absolute bioavailability of ospemifene has not been established.
Ospemifene is primarily metabolised by the liver.
Two different ospemifene tablets were made.
Ospemifene is a selective estrogen receptor modulator.
There are no data on the use of ospemifene in pregnant women.
Effects of ospemifene on other medicinal products.
There is no specific antidote for ospemifene.
Ospemifene is used to treat dyspareunia.
The active substance is ospemifene.
Ospemifene is an especially valuable drug because it has an excellent tolerability.
A clinical monitoring of a decrease in the efficacy of ospemifene should be made.
Ospemifene should only be continued as long as the benefit outweighs the risk.
See also
The new and surprising effect of ospemifene was found in a clinical study.
In patients with moderate hepatic impairment the exposure of ospemifene and.
Ospemifene has not been formally studied in women with a prior history of breast cancer.
The risk of cerebrovascular events associated with ospemifene can not be excluded.
It is unknown if ospemifene is a substrate for BCRP in the intestine.
The reproductive effects observed are considered to be related to oestrogen receptor activity of ospemifene.
Preclinical and clinical data show that ospemifene is well tolerated with no major side effects.
It is recommended that any additional pathology be investigated and treated appropriately before starting ospemifene.
Known methods for the syntheses of compounds like ospemifene and fispemifene include rather many steps.
SUMMARY Both ospemifene and fispemifene are likely to be commercialized in the near future.
A particular form of atrophy which can be inhibited by administering of ospemifene is urogenital atrophy.
Ospemifene improved post-menopausal physiologic changes.
Therefore care should be taken if ospemifene is administered with a BCRP inhibitor.
Post-marketing experience with ospemifene.
If pregnancy occurs during treatment with ospemifene, ospemifene should be withdrawn immediately.
As such, many of the effects produced by estrogens are produced by ospemifene.
The risk of VTE associated with ospemifene can not be excluded.
Instead, stimulation of bile flow due to meal ingestion may enhance the solubilisation of ospemifene.
Therefore, caution is recommended when ospemifene is combined with orlistat.
In the uterus ospemifene and its major metabolite have weak partial agonist / antagonist effects.
Paediatric population Pharmacokinetic studies have not been performed with ospemifene in the paediatric population.
Ospemifene is an Estrogen agonist / antagonist with tissue selective effects.
Therefore, caution is recommended when co-administering ospemifene with fluconazole.
In bone, ospemifene has agonist-like activity.
No food was allowed for at least 4 hours after the ospemifene dose.
The most important metabolite of ospemifene 4-hydroxyospemifene, which has the formula.
In the liver, an increase in hepatocellular tumours were recorded at all ospemifene dose levels.
The apparent terminal half-life of ospemifene in post-menopausal women is approximately 25 hours.
Particularly compared to the behaviour of other SERMs, the food effect on ospemifene is remarkable.
Less than 0.2 % of the ospemifene dose was excreted unchanged in urine.
The meal had to be consumed over the 30 minutes, immediately followed by administration of ospemifene.
Furthermore in vitro studies have shown that ospemifene is a weak inducer for CYP2B6 and CYP3A4.
In clinical trials, a single MI occurred in a woman receiving ospemifene 60 mg.
A dose-response also was observed in the trial; ospemifene 60 mg had greater efficacy than ospemifene 30 mg.
Each film-coated tablet contains 60 mg ospemifene.
