Examples of 'p-glycoprotein' in a sentence
Meaning of "p-glycoprotein"
p-glycoprotein (noun): A type of protein that plays a role in transporting molecules across cell membranes. It is particularly important in the removal of toxins from cells
How to use "p-glycoprotein" in a sentence
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p-glycoprotein
P-glycoprotein is also believed to be involved in multidrug resistance.
Sitagliptin may be a mild inhibitor of p-glycoprotein in vivo.
P-glycoprotein is not just found in tumor cells.
Medicinal products that affect the p-glycoprotein transporter.
Various p-glycoprotein inhibitors are well known and appreciated in the art.
Macrocyclic lactones including moxidectin have been shown to be substrates for p-glycoprotein.
Research on p-glycoprotein and other such chemotherapy efflux pumps is currently ongoing.
Therefore, meaningful interactions would not be expected with other p-glycoprotein inhibitors.
Ketoconazole is a p-glycoprotein inhibitor and can have serious interactions with other medications.
Furthermore, clinical data do not suggest interaction with p-glycoprotein inhibitors or substrates.
P-glycoprotein is a pump that localizes to the apical membrane of cells, forming polarized monolayers.
Medications inhibiting the function of p-glycoprotein have been explored to enhance the efficacy of chemotherapy.
These findings underscore the need to classify antidepressants according to their property as p-glycoprotein substrate.
Dabigatran etexilate used with p-glycoprotein inducers require monitoring of decreased levels and effects of dabigatran.
Paliperidone in high concentrations is a weak inhibitor of P-glycoprotein.
See also
They are used to synthesize a P-glycoprotein sequence or sequences.
Maraviroc is a substrate for the efflux transporter P-glycoprotein.
Substances transported by P-glycoprotein or other transporters.
Ritonavir can inhibit the activity of P-glycoprotein.
The transporter P-glycoprotein exists already in the embryonal endothelium.
No significant influence known with P-glycoprotein transporters.
Mammalian P-glycoprotein family members can be divided into three classes.
The best known of these transporters is P-glycoprotein.
Erlotinib is a substrate for the P-glycoprotein active substance transporter.
In vitro studies indicated that axitinib inhibits P-glycoprotein.
Consequently, upregulation of P-glycoprotein usually results in resistance to multiple drugs.
Silodosin is also a substrate for P-glycoprotein.
The inhibitory effect of rifaximin on P-glycoprotein transport was observed in an in vitro study.
Fampridine is not a substrate for P-glycoprotein.
Potent P-glycoprotein inhibitors such as ciclosporin and verapamil should also be avoided.
Pomalidomide is also a substrate of P-glycoprotein in vitro.
This tumor overexpresses P-glycoprotein and is resistant to paclitaxel and vinca alkaloids.
Spinosad has been shown to be a substrate for P-glycoprotein PgP.
A multidrug resistance gene encoding P-glycoprotein is also specifically contemplated as the heterologous gene.
Interactions with medicinal products that are P-glycoprotein substrates.
High levels of p-glycoprotein are associated with amplification of the MDR gene and transcriptional activation.
The mechanism for this interaction may be induction of P-glycoprotein.
However, axitinib is not expected to inhibit P-glycoprotein at therapeutic plasma concentrations.
Its primary use is as an inhibitor of the efflux transporter P-glycoprotein.
Plasma concentrations may be increased due to P-glycoprotein inhibition by lopinavir / ritonavir.
Based on in vitro data pasireotide appears to be a substrate of efflux transporter P-gp P-glycoprotein.
Such constructs would change expression levels of a P-glycoprotein in the plant or plant cell.
Specific blockade of P-glycoprotein can suppress the immune response to alloantigen and nominal antigen.
It is also a substrate for P-glycoprotein.
The drug efflux pump P-glycoprotein mediates a majority of the MDR associated with cytotoxic chemotherapeutics.
Plerixafor did not act as a substrate or inhibitor of P-glycoprotein in an in vitro study.
P-glycoprotein P-gp is a known BBB active efflux transporter involved in neuroprotection.
Elagolix itself is an inhibitor of P-glycoprotein.
Interaction with P-glycoprotein inhibitors.
Rimonabant displays high in vitro permeability and is not a substrate of P-glycoprotein.
