Examples of 'peptidomimetic macrocycle' in a sentence
Meaning of "peptidomimetic macrocycle"
peptidomimetic macrocycle - A peptidomimetic macrocycle is a chemical compound designed to mimic the structure of peptides or proteins in a cyclic form
How to use "peptidomimetic macrocycle" in a sentence
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peptidomimetic macrocycle
The peptidomimetic macrocycle may be purified after the contacting step.
A pharmaceutical composition comprising the peptidomimetic macrocycle as claimed in claim 1.
The peptidomimetic macrocycle may be refolded after the contacting step.
Additionally, disclosed is a pharmaceutical composition comprising the peptidomimetic macrocycle of the invention.
The peptidomimetic macrocycle comprises at least one a-helix motif.
A macrocycle-forming linker may increase cell permeability of the peptidomimetic macrocycle.
The peptidomimetic macrocycle is refolded after the contacting step ;.
In some embodiments, a macrocycle-forming linker increases cell permeability of the peptidomimetic macrocycle.
In other cases, the peptidomimetic macrocycle is purified after the contacting step.
In some embodiments, the macrocycle-forming linker stabilizes an a-helix motif included within the peptidomimetic macrocycle.
In some embodiments, the peptidomimetic macrocycle comprises at least one a-helix motif.
FIG . 4 shows helical wheel representations of improved peptidomimetic macrocycle analogs.
The peptidomimetic macrocycle resulting from a method of the invention comprises a-helix in aqueous solution.
In some embodiments, the peptidomimetic macrocycle comprises an a-helix.
The peptidomimetic macrocycle exhibits increased thermal stability compared to a corresponding non-macrocyclic polypeptide ;.
See also
In some embodiments, the peptidomimetic macrocycle comprises an â–¡ - helix.
The peptidomimetic macrocycle exhibits increased biological activity compared to a corresponding non-macrocyclic polypeptide ;.
In still other embodiments, the peptidomimetic macrocycle is refolded after the contacting step.
The peptidomimetic macrocycle exhibits increased resistance to proteolytic degradation compared to a corresponding non-macrocyclic polypeptide ; or.
The peptidomimetic macrocycle of claim 1 wherein I is of the formula.
The peptidomimetic macrocycle comprises an a-helix in aqueous solution ;.
The peptidomimetic macrocycle of claim 1, wherein.
The peptidomimetic macrocycle of claim 1 wherein the peptidomimetic macrocycle comprises an a-helix and,.
The peptidomimetic macrocycle of claim 5 wherein the macrocycle-forming linker spans 1 turn of the a-helix, wherein.
The peptidomimetic macrocycle of claim 1 wherein the macrocycle-forming linker spans 2 turns of the a-helix, wherein.
The peptidomimetic macrocycle of claim 1, wherein I is.
The peptidomimetic macrocycle of claim 5 wherein the a-helix comprises 2 turns, wherein.
The peptidomimetic macrocycle of claim 12, wherein the a-helix comprises from 1 turn to 5 turns.
A peptidomimetic macrocycle comprising an a-helix of Formula ( I ), wherein,.
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One bicyclic macrocycle plus peptide or drug
Heme group of hemoglobin with a porphin macrocycle
The macrocycle may be symmetrical or asymmetrical
Examples of using Peptidomimetic
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Thus a peptidomimetic is an isostere of the corresponding peptide
These compounds have a peptidomimetic structure
Peptidomimetic cyclic compounds for treating retinitis pigmentosa
