Examples of 'polysialic acid' in a sentence
Meaning of "polysialic acid"
polysialic acid: Polysialic acid is a type of carbohydrate polymer composed of repeating units of sialic acid. It is found in certain tissues and can play a role in various biological functions, such as cell adhesion and signaling
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- A polymeric form of sialic acid that is involved in cell adhesion
How to use "polysialic acid" in a sentence
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polysialic acid
The polysialic acid can be a branched or unbranched polymer.
An example for a polysaccharide is polysialic acid.
Polysialic acid has extensive applications in the pharmacology.
Also suitable are pharmaceutically acceptable salts of the polysialic acid.
Polysialic acid is considerably anionic.
The retention time showed the exact length of the polysialic acid.
Oligosialic and polysialic acid are extended homopolymers of sialic acid.
A compound according to any preceding claim in which the polysaccharide is a polysialic acid.
Extended polysialic acid chains have been observed on glycoproteins of human neuroblastoma.
The moiety may be generated by reaction of a polysialic acid substrate with a heterobifunctional reagent.
The polysialic acid preferably consists substantially only of sialic acid units.
The new form involves chemical modifications to both termini of the natural polysialic acid molecule.
The polysialic acid may be in the form of a salt or the free acid.
In another preferred embodiment, the linker further comprises a polysialic acid linker.
Polysialic acid and use for treatment of neurodegenerative and neuroinflammatory diseases.
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Preferably, the polysaccharide is polysialic acid and consists substantially only of sialic acid units.
Polysialic acid is highly hydrophilic whereas PEG is amphiphilic.
The Neu5Ac monomer units of the polysialic acid polysaccharide are joined together by glycosidic bonds.
Polysialic acid is highly hydrophilic whereas PEG is an ampiphilic molecule in nature.
During this step, substantially all of the polysialic acid remains on the ion exchange resin.
Recovering polysialic acid having reduced endotoxin content from the solution.
The new method is of particular value for creation of a monofunctional polysialic acid ( PSA ).
The polysialic acid obtained by the instant invention has higher molecular weight.
The group R1 may comprise a linker moiety from the active compound to the polysialic acid.
The polysialic acid of the present disclosure can be derived from natural or synthetic sources.
A compound according to claim 30 wherein the oligo - or polysaccharide is an oligo - or polysialic acid.
Polysialic acid is highly hydrophilic whereas PEG is an amphiphilic molecule in nature.
The compound according to claim 5, wherein said polysaccharide is polysialic acid ( PSA ).
Preferably, the polysialic acid is an unbranched polymer.
In another embodiment, the physiologically acceptable linker is polysialic acid ( PSA ) and / or derivatives thereof.
Further, polysialic acid can be derived from a dietary source.
Antibodies elicited by MenB PS cross-react with host polysialic acid ( PSA ).
Further, polysialic acid has been used to improve the pharmacokinetics of proteins.
Figure 1 the characterization of polysialic acid ( PSA ) fragments.
Preferably, the polysialic acid is in the form of the free polysaccharide.
Neu5Ac monomers linked by a 2.8 linkage correspond to the human form of polysialic acid.
Polysialic acid ( PSA ) is a relatively new biocompatible and bioresorbable material for artificial nerve conduits.
Unlike other polymers ( eg . PEG ), polysialic acid is biodegradable.
The polysialic acid derivatives may have general formula ( I ).
Determination of the effect of low molecular weight polysialic acid ( PSA-20 ) on microglial neurotoxicity.
Polysialic acid is a carbohydrate composed of a linear homopolymer of a-2,8-linked sialic acid residues.
Preferably, the resultant polysialic acid derivative has a polydispersity of less than 1.1.
Polysialic acid ( PSA ), also referred to as colominic acid ( CA ), is a naturally occurring polysaccharide.
It could be shown that the polysialic acid ( 1 ) showed no neurotoxicity in cultured human neurons.
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