Examples of 'pparδ' in a sentence
Meaning of "pparδ"
pparδ (noun) - a type of protein that plays a role in gene expression and other biological processes
How to use "pparδ" in a sentence
Basic
Advanced
pparδ
Deletion of PPARδ provokes spontaneous cardiac remodeling.
More preferably they are selective PPARδ agonists.
Increase of PPARδ expression can be achieved either directly or indirectly.
It is preferred if the inhibitor of PPARδ activity is selective for PPARδ.
Deletion of PPARδ causes rapid biventricular dilation and premature death.
This assay determines whether the test compound binds PPARδ.
The physiological function PPARδ is not completely understood.
The inhibitor may be one which prevents the expression of PPARδ in a cell.
These PPARδ selective agonists unexpectedly lower triglycerides and insulin levels in the primate.
The compound is one which inhibits the activity of PPARδ protein activity.
This data reveals that PPARδ mediates the fatty acid repression of the apoE gene expression.
A decrease in the radioactivity bound will indicate the presence of a competing PPARδ compound.
PPARδ is observed in both embryo and adult tissues.
Counteracting any of these microRNAs are useful for increasing or restoring the expression of PPARδ.
Initial differentiation experiments were performed with the PPARδ cell lines in the selection medium.
See also
PPARδ is expressed ubiquitously in the tissues of organisms with nerve cells as the center.
A new class of compounds that modulate PPARY or PPARδ has now been discovered.
PPARδ has protein heterodimerization activity and retinoid X receptor binding activity.
Activation of PPARa or PPARδ leads to increased fatty acid B oxidation.
At present, the physiological significance of PPARδ is still unclear.
Also, the PPARδ is known to be universally expressed without tissue specificity.
However, no mention is given with respect to an effect as PPARδ ligand.
Figure 9 shows that inhibition of PPARδ prevents foam cell formation.
Figure 5 shows the generation of cell lines constitutively expressing PPARδ.
We have shown that inhibition of PPARδ activity inhibits PMA-stimulated proliferation of cells.
As is described above, the compounds of the invention are strong PPARδ agonists.
The co-activator PPARδ helps regulate the protein expression involving an expenditure of energy.
Figure 8 shows that ApoE gene expression is regulated by fatty acids through PPARδ.
Evidence suggests that PPARδ controls the peroxisomal beta-oxidation pathway of fatty acids.
Figure 7 shows that fatty acid efflux is repressed in activated PPARδ over-expressing cells.
PPARδ expression is ubiquitous ; the function of this receptor has not yet been determined.
The term " inhibitor of PEARδ activity " includes compounds which block the effect of PPARδ agonists.
PPARδ compounds are useful for, among other things ; lowering triglyceride levels or raising HDL levels.
Similarly, screens may be carried out to determine the compounds selectivity for inhibiting PPARδ activity.
TNF-a also triggers production of endogenous PPARδ ligands, which activate PPARδ in keratinocytes and macrophages.
PPARa is mainly expressed in the liver, whereas PPARδ is ubiquitous.
These PPARδ anti-sense cells grow normally with high viability in the absence of PMA.
PPARa is mainly expressed in the liver, while PPARδ is ubiquitous.
PPARoc, PPARY and PPARδ have been identified as subtypes of PPARs.
Cultures with low B-galactosidase activity indicate the presence of a PPARδ antagonist.
PPARδ is involved in the action of the tumour promoter, PMA.
The compound of Example 5 shows the particularly strong agonist function for PPARδ.
Three subtypes have been described which are PPARa, PPARδ also known as PPARB, and PPAY.
The level of PPARδ remains constant from day 0 to day 7.
Apparently, the compounds of the invention having the general formula ( I ) show potent PPARδ transactivation activities.
The PPARδ / coactivator.
It has been found that compound A activates each of the PPARa, PPARY and PPARδ receptors.
Figure 10 shows that PPARδ protection from death is not downstream of PKC.
Through manipulation of transcription factors that regulate miR-214, thereby indirectly increasing the expression of PPARδ.
Three subtypes have been described which are PPARa, PPARδ ( also known as PPARB ), and PPARY.
