Examples of 'ppara' in a sentence
Meaning of "ppara"
PPARA (noun): An abbreviation used to refer to peroxisome proliferator-activated receptor alpha, a type of nuclear receptor protein involved in the regulation of genes responsible for fatty acid metabolism
How to use "ppara" in a sentence
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ppara
Fibrates can be cited as PPARa activators or agonists.
The PPARa agonist may for example be a fibrate.
This decrease is characteristic of the effects of PPARa activators.
Useful examples of PPARa activators include fibrates.
A therapeutic compound disclosed herein may be a PPARa agonist.
This is consistent with PPARa having a role in skin physiology.
Most changes were associated with the PPARa receptor.
Useful examples of PPARa activators include fibric acid derivatives or fibrates.
Cotransfection efficacy was determined relative to PPARa agonist reference molecules.
The use of PPARa agonists is known for the treatment of elevated triglycerides.
Cotransfection efficacy is determined relative to PPARa agonist reference molecules.
These results suggest that the compounds of the invention act vía PPARa.
The compounds preferably indicated as PPARa agonists are compounds belonging to the fibrate class.
Fenofibrate faithfully modified the expression of PPARa responsive genes.
PPARa is also known to be involved in inflammatory disorders.
See also
Human hepatocytes were successfully used in cellular toxicity studies of PPARa agonists.
PPARa is known to be an important regulator of fatty acid oxidation.
Surprisingly a series of compounds has now been found which are selective PPARa modulators.
PPARa activators are also capable of correcting hyperglycemia and insulin level.
Surprisingly a series of compounds has now been found which are highly potent PPARa modulators.
PPARa receptors also modulate the profibrolic response to different stimuli.
The role of metabolites of DHEA on activation of PPARa are under study.
PPARa receptors also modulate the profibrotic response to different stimuli.
More preferably they are also agonists of at least one of PPARY or PPARa.
PPARa is a molecular sensor of endogenous fatty acids and their derivatives.
Other agents have a function as a dual agonist for PPARY and PPARa.
Activators of PPARa and PPARY have overlapping as well as distinct pharmacological effects.
Preferred PPAR activators according to the present invention are agonists of PPARa activity.
PPARa is also involved with the activity of fibrates in rodents and humans.
Cotransfection efficacy is determined relative to PPARa agonist and PPARY agonist reference molecules.
PPARa and PPARY control the expression of genes involved in fatty acid and energy utilisation.
Cotransfection efficacy was determined relative to PPARa agonist and PPARB agonist reference molecules.
PPARa regulates the metabolism of lipids.
Cotransfection efficacy was determined relative to PPARa agonist and PPARY agonist reference molecules.
Activation of PPARa or PPARδ leads to increased fatty acid B oxidation.
The following examples demonstrate that the inventive compounds activate PPARa and PPARY in vitro.
PPARa and apoAI show attenuated induction whereas GPAT exhibits an attenuated fasting repression.
Aleglitazar is capable of binding and activating both PPARa and PPARY simultaneously and very efficiently.
In particular the compounds of formula I are highly potent agonists of PPARa.
PPARa is another subtype of the PPAR family.
The following experimental data show that the inventive compounds activate PPARa and PPARY in vitro.
PPARa was activated to a greater extent than either PPARB or PPARY.
PPAR activators according to the present invention are activators of PPARa and PPARY.
Of these subtypes, PPARa is mainly expressed in the liver.
PPARa is mainly expressed in the liver, whereas PPARδ is ubiquitous.
Among them, fibrates can be cited as PPARa activators or agonists.
The identification of PPARa agonists is done by in-vitro screening based on cell biology techniques.
Also, the transcription-activating function of PPARa is never satisfied in strength.
In another embodiment, the PPARa agonist and the metformin are administered simultaneously or co-administered.
For some promoters the GR effect seems to predominate, for others PPARa.
