Examples of 'pro-drug' in a sentence
Meaning of "pro-drug"
Pro-drug (noun): A compound that is pharmacologically inactive but can be metabolized within the body into an active drug. These compounds are designed to improve the delivery, absorption, distribution, and elimination of active drugs
How to use "pro-drug" in a sentence
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pro-drug
Codeine is actually a pro-drug that is converted to morphine.
A pro-drug serves as a type of precursor to the intended drug.
Proteins can also be pro-drug converting enzymes.
The compounds may be administered in the form of a pro-drug.
Remogliflozin etabonate is a pro-drug of remogliflozin.
An appropriate pro-drug is administered in conjunction with the vector.
One particularly useful form of a pro-drug is an ester derivative.
It is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir.
The NOIs may also encode pro-drug activating enzymes.
Pro-drug may be given as a series of bolus injections or by continuous infusion.
Sodium phenylbutyrate is a pro-drug and is rapidly metabolised to phenylacetate.
Sentences have never been given for publishing pro-drug propaganda.
A wide variety of pro-drug formulations are known in the art.
The term is thus to be understood as defining regular pro-drug forms.
Capecitabine is a pro-drug which converts to fluorouracil in the tumour.
See also
In this manner such lipophilic modifications may be considered as a pro-drug.
Oseltamivir phosphate is a pro-drug of the active metabolite oseltamivir carboxylate.
The pharmaceutical composition of the invention may constitute a pro-drug.
Suitable pro-drug formulations according to the invention were selected as follows.
Another method involves developing a pro-drug of the peptide of interest.
The pharmaceutically active substance may be in the form of a pro-drug.
Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole.
The compounds of the invention may be administered in the form of a pro-drug.
The efficacy of a pro-drug depends on the amount of formed active metabolites.
In free acid form or in salt, physiologically hydrolysable ester or pro-drug form.
In terms of developing new drugs the pro-drug concept is of particular relevance.
Such pro-drug forms typically demonstrate little or no activity in in vitro assays.
Such genes include those encoding pro-drug activators or immunostimulatory proteins.
It is a pro-drug and is both pharmacologically and structurally associated with meprobamate.
In addition, the compounds of the present invention may be provided as a pro-drug.
A derivative or pro-drug can have enhanced permeability for a target organ.
The composition will conveniently comprise an effective amount of the pro-drug.
Capecitabine is a pro-drug which is readily absorbed from the gastrointestinal tract.
The resulting product is then deprotected to provide the desired pro-drug ester.
Various forms of pro-drug have been described, for example in the following documents.
In this manner such lipophilic modifications may be considered as having a pro-drug effect.
Such genes include those encoding pro-drug activators or immune stimulatory proteins.
A sealant or barrier layer is not intended to modify the release of drug or pro-drug.
The cancer therapeutic pro-drug tegafur was tested in the microscale chip system.
These conjugates may be cleavable such that the conjugate behaves as a pro-drug.
Etopophos contains etoposide phosphate, a pro-drug of etoposide which is rapidly converted to etoposide in vivo.
The intermediate layer includes a permeating bioactive substance such as a drug or pro-drug.
A pro-drug may be converted to the active pharmaceutical species by hydrolytic, enzymatic, or metabolic transformations.
After infusion of colistimethate sodium the inactive pro-drug is converted to the active colistin.
In said case, the pharmaceutical composition is one single molecule and is also a pro-drug.
In certain pharmaceceutical dosage forms, the pro-drug form of the compounds may be preferred.
Indoxacarb is a pro-drug that requires bioactivation by the insect enzymes to exert its pharmacodynamic effects.
It was originally believed that these compounds would generally function as pro-drug delivery compounds.
Kinetics of conversion from pro-drug to drug when incubated with a rat or human brain extract.
Only target cells or organisms which express the enzyme will be affected by the pro-drug.
