Examples of 'proteasome inhibitors' in a sentence
Meaning of "proteasome inhibitors"
proteasome inhibitors - Refers to substances or drugs that block the action of proteasomes, which are enzymes involved in protein degradation within cells
How to use "proteasome inhibitors" in a sentence
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proteasome inhibitors
Proteasome inhibitors are described in further detail herein.
The same hypothesis applies to the proteasome inhibitors.
New proteasome inhibitors are now in development.
Erlotinib and proteasome inhibitors.
Proteasome inhibitors for treating cancer.
The following is a review of the drug class known as proteasome inhibitors.
Proteasome inhibitors include natural and synthetic compounds.
Suspensions may be preferred for proteasome inhibitors which are sparingly soluble in water.
Proteasome inhibitors such as bortezomib.
It is seen that compounds that are proteasome inhibitors also enhance bone formation.
Several proteasome inhibitors are marketed or are being studied in the treatment of cancer.
Velcade is the first in a new class of anticancer agents known as proteasome inhibitors.
Some further proteasome inhibitors can contain boron moieties.
Thus inhibiting degradation of cyclins by using proteasome inhibitors causes growth arrest.
Proteasome inhibitors may also play a role as radiation sensitizers.
See also
Drug treatments that block proteasomes from working are called proteasome inhibitors.
The proteasome inhibitors are preferably administered topically to the eye.
The present disclosure expands the use of proteasome inhibitors for therapy.
Proteasome inhibitors are designed to limit the effects of a cell structure called a proteasome.
Have described peptide boronic ester and acid compounds useful as proteasome inhibitors.
Proteasome inhibitors have also shown promise in treating autoimmune diseases in animal models.
The present inventors have discovered that these standard procedures are unsuitable for proteasome inhibitors.
Examples of the proteasome inhibitors include Bortezomib.
Therefore the invention also relates to the elicitation of T cells with proteasome inhibitors.
Examples of the proteasome inhibitors include Bortezomib and the like.
Detailed Description of the Invention Many proteasome inhibitors are known.
Such proteasome inhibitors include inter alia e . g.
In some of the foregoing embodiments, the subject is resistant to proteasome inhibitors.
Suitable proteasome inhibitors for use in combination herein include,.
Yet most cancers maintain a pre-existing resistance to such proteasome inhibitors.
Proteasome inhibitors include, but are not limited to, lactacystin and bortezomib.
Tyrosine kinase inhibitors and proteasome inhibitors are examples of small-molecule drugs.
Proteasome inhibitors are currently in trials as treatments for some diseases, such as cancer.
There is thus a continuing need for new and / or improved proteasome inhibitors.
Proteasome inhibitors for treating a disorder related to an accumulation of non-degraded abnormal protein or a cancer.
In more specific embodiments, the compounds described herein synergistically augment proteasome inhibitors.
By contrast, stimulated cells treated with proteasome inhibitors accumulate both phosphorylated and unphosphorylated IkBa.
These experiments are advantageously carried out after treatment of cells with proteasome inhibitors e . g.
Proteasome inhibitors reduce SRSF1 levels in two cultured human adenocarcinoma cell lines.
Compounds known to be proteasome or NF-kB inhibitors include, Proteasome Inhibitors.
The use of proteasome inhibitors on an OPMD model is shown in Example 3.
Inhibiting p53 degradation by the topical application of proteasome inhibitors provides a method to enhance the p53 response.
Proteasome inhibitors such as bortezomib, carfilzomib, and ixazomib ;.
Non-limiting examples of non-peptide proteasome inhibitors include omuralide and the compound of formula ( I ).
Proteasome inhibitors also block IkB-a degradation and NF-kB activation Palombella, et al.
The two cell lines were incubated for 24h with 3 concentrations of proteasome inhibitors diluted in DMSO.
For example, proteasome inhibitors can modulate, such as induce, apoptosis in a cell.
Deboronated-bortezomib metabolites are inactive as 26S proteasome inhibitors.
Two such chemicals - proteasome inhibitors and activin inhibitors6 - are under clinical trials.
Proteasome inhibitors such as Bortezomib ( Velcade ).
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Similar proteasome inhibition by carfilzomib was achieved with
The biological consequences of proteasome inhibition are numerous
The proteasome participates in the degradation ofcyclins
