Examples of 'reductive alkylation' in a sentence
Meaning of "reductive alkylation"
This is a technical term used in organic chemistry to describe a specific type of chemical reaction. It involves the addition of an alkyl group to a molecule by reducing another functional group
How to use "reductive alkylation" in a sentence
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reductive alkylation
Suitable conditions can be reductive alkylation conditions.
Reductive alkylation may also be carried out in two steps.
Process for the reductive alkylation of normorphinans.
Reductive alkylation according to method d is performed by standard literature procedures.
The preferred method is reductive alkylation.
The reductive alkylation according to method c is performed by standard literature methods.
The second step comprises reductive alkylation of the corresponding amine.
An alternative method for alkylation of the amine nitrogen is reductive alkylation.
The reducing agent used in the reductive alkylation of an amine was sodium cyanoborohydride.
The reaction is carried out under conditions suitable for reductive alkylation.
Another preferred chemical reaction is reductive alkylation at the amino group of mycosamine.
The illustrated example uses benzaldehyde as a substrate for the reductive alkylation.
Codeine can also be obtained by reductive alkylation of norcodeine with formaldehyde and borohydride.
Alkylation may typically be carried by treatment with an alkyl halide or by reductive alkylation.
Any suitable base can be employed in the reductive alkylation process of the invention.
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After the reductive alkylation a second alkyl group may be introduced as described above.
Any glycopeptide having an amino group may be employed in these reductive alkylation reactions.
The preferred solvents for the reductive alkylation include methanol and dichloromethane.
The reductive alkylation may be carried out with hydrogen and a platinum catalyst.
The amino group can then be alkylated using standard reductive alkylation procedures.
The reductive alkylation thus functions as a dynamic sieve which isolates the target diamine.
Furthermore these peptide resins were also modified by reductive alkylation prior to permethylation and perallylation.
By reductive alkylation of the compound of formula IV below.
The procedure is essentially as described above except for the following reductive alkylation step.
This bond is then stabilized through reductive alkylation with a low concentration of sodium cyanoborohydride.
The amine thus formed can now be functionalized under standard reductive alkylation procedures.
General procedure for the reductive alkylation preparation of compounds of Formula IX.
The Rc group is then attached to nitrogen either by alkylation or reductive alkylation.
General procedure for the reductive alkylation preparation of compounds of Formula VIII.
In some embodiments, this type of bond is formed by a reductive alkylation reaction.
A preferred reductive alkylation catalyst is borane, pyridine complex.
Scheme F illustrates another method for reductive alkylation of a glycopeptide.
The reductive alkylation also can be performed by using a Dean-Stark.
In some instances, this type of bond is formed by a reductive alkylation reaction.
The reductive alkylation is typically carried using an excess of the dialdehyde 2.
Suitably, the alkylation or aralkylation is carried out by reductive alkylation or reductive aralkylation.
The reductive alkylation according to methods 2 and 7 is performed by standard literature methods.
In one particular embodiment, the mixed polycycloaliphatic amines are prepared using a reductive alkylation method.
Alternatively, a homogeneous reductive alkylation reagent such as sodium cyanoborohydride may be employed.
These results clearly show that the IL10 kinoid was effectively inactivated by the reductive alkylation.
Often, they are prepared by reductive alkylation of primary amines with aldehydes or ketones.
Product 10 may be obtained from 7 by two routes, conventional alkylation or reductive alkylation.
This reaction is conducted under reductive alkylation conditions to yield a glycopeptide intermediate 11.
Reductive alkylation of 9b using formaldehyde and Raney nickel under a hydrogen atmosphere yielded 5f.
Figure 2R illustrates the reductive alkylation of amines of morpholino oligomers.
Reductive alkylation with acetaldehyde in the presence of lithium cyanoborohydride gives the corresponding N-ethyl derivative.
Example 3 illustrates the present reductive alkylation in N-terminally pegylating consensus interferon.
Reductive alkylation or nucleophilic displacement of iodine gives chloride 11.
The compound of formula ( IV ) is obtained by the above reductive alkylation reaction described above.
The reductive alkylation reaction may be performed using conditions and reagents, as described above.
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