Examples of 'retigabine' in a sentence
Meaning of "retigabine"
retigabine (verb) - a pharmaceutical drug that acts as a potassium channel opener and is used in the treatment of epilepsy
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- An anticonvulsant drug.
How to use "retigabine" in a sentence
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retigabine
Trobalt contains the active substance retigabine.
Retigabine had no effect on fertility or general reproductive performance.
There is limited experience of overdose with retigabine.
It is unknown whether retigabine is excreted in human breast milk.
Retigabine is also active in several other seizure models.
Clinical efficacy of adjunctive retigabine therapy in partial onset seizures.
Retigabine and its metabolites are eliminated principally by renal excretion.
Trobalt is a medicine that contains the active substance retigabine.
The activity of retigabine is shown for comparative purposes.
The active substance is retigabine.
The effect of retigabine on human fertility has not been established.
There are no adequate data from the use of retigabine in pregnant women.
Retigabine is extensively metabolised in humans.
Reversibility of retinal pigmentation after retigabine discontinuation has been reported in some subjects.
Retigabine appears to be free of drug interactions with most commonly used anticonvulsants.
See also
These compounds may have reduced untoward side effects as compared to retigabine.
Elimination of retigabine occurs via a combination of hepatic metabolism and renal excretion.
Examples of preferred potassium channel modulators such as but not limited to retigabine.
Concomitant use of retigabine and digoxin may increase serum concentration of the latter.
Symptoms and signs There is limited experience of overdose with retigabine.
Retigabine may increase the duration of anaesthesia induced by some anaesthetics for example thiopental sodium.
There were no treatment-related effects of retigabine on fertility in animal studies.
Retigabine has also been found to be useful in treating pain, including neuropathic pain.
However, efficacy and safety of retigabine have not been determined in adolescents.
Retigabine has been found to be particularly potent in models for drug-refractory epilepsy.
In a population pharmacokinetic analysis, retigabine clearance increased with increasing body surface area.
When the study was conducted, Porter worked for Wyeth Pharmaceuticals, which developed retigabine.
The pharmacokinetics of retigabine in children below 12 years of age have not been investigated.
Haemodialysis has been shown to reduce the plasma concentrations of retigabine and NAMR by approximately 50.
Phenytoin can reduce retigabine systemic exposure by 35 % carbamazepine can reduce retigabine systemic exposure by 33.
NAMR has antiepileptic activity, but is less potent than retigabine in animal seizure models.
Retigabine is metabolized in the liver, by N-glucuronidation and acetylation.
A substantial fraction of the retigabine dose is converted to inactive N-glucuronides.
Retigabine is also metabolised to an N-acetyl metabolite ( NAMR ) that is also subsequently glucuronidated.
The steady state volume of distribution of retigabine is 2 to 3 l / kg following intravenous dosing.
Retigabine has a plasma half-life of approximately 6 to 10 hours.
There is no evidence for hepatic oxidative metabolism of retigabine or NAMR by cytochrome P450 enzymes.
Retigabine and its metabolites are excreted almost completely ( 84 % ) by the kidneys.
The company is withdrawing retigabine from clinical use in 2017.
Each tablet contains 50 mg retigabine.
