Examples of 'scaffold protein' in a sentence
Meaning of "scaffold protein"
scaffold protein: In biology, a scaffold protein serves as a structural component that helps organize and regulate cellular activities by bringing together various molecules or signaling pathways
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- Proteins that bring together various other proteins in a signaling pathway and allow for their interaction. They recruit downstream effectors in a pathway and enhance specificity of the signal.
How to use "scaffold protein" in a sentence
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scaffold protein
The scaffold protein could be a detectable protein.
Suitably the molecule comprises a scaffold protein.
Preferably a scaffold protein has no hinge region.
The cell can express a fibronectin based scaffold protein.
A scaffold protein is preferably biologically neutral.
Modifications to the fibronectin based scaffold protein can also be produced by chemical synthesis.
A scaffold protein must be able to accept a peptide insert.
Mutations may be introduced into a fibronectin based scaffold protein coding sequence to generate cysteine residues.
A scaffold protein must be of known structure.
This interaction influences the oligomerization of the scaffold protein but also the nanodiscs homogeneity.
A scaffold protein should be small.
There are many advantages to using the Tf as the scaffold protein in a peptide library.
Preferably the scaffold protein of the invention is immobilised.
Sequence operably linked to the DNA encoding the fibronectin based scaffold protein.
The fibronectin based scaffold protein may be immobilized on a solid support.
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In one aspect, the cell expresses a fibronectin based scaffold protein.
An interaction between the scaffold protein and divalent cations has been revealed.
The method according to claim 5, wherein said polypeptide comprises a scaffold protein.
The scaffold protein may be any protein having good solubility properties.
The present invention provides Tf as the scaffold protein for generating peptide libraries.
Preferably a scaffold protein has no other domain known to facilitate conformational changes.
In some embodiments, administration of a fibronectin based scaffold protein treats an aritiproliferative disorder in a subject.
Preferably a scaffold protein according to the present invention will be conformationally stable.
Preferably, the target peptide shows increased stability in the context of the scaffold protein.
Preferably a scaffold protein according to the present invention has no post translational modifications.
In some embodiments, administration of a fibronectin based scaffold protein inhibits tumor cell growth in vivo.
Preferably a scaffold protein provides the target peptide with an increased stability in vivo.
A “ peptide aptamer ” is a combinatorial protein molecule with a variable peptide sequence inserted within a constant scaffold protein.
The fibronectin based scaffold protein is then purified from culture media or cell extracts.
In some embodiments, one PEG moiety is conjugated to the fibronectin based scaffold protein.
Preferably a scaffold protein has no Proline rich domain.
In this example, human trypsin I was used as the scaffold protein.
Preferably a scaffold protein has no PH domain.
Mitogen-activated protein kinase scaffold protein 1.
Preferably, the scaffold protein is a small globular protein.
The monoclonal antibody according to claim 1, which is a scaffold protein.
Talin is a central scaffold protein in integrin-mediated cell adhesions.
When expressed, “ prey ” peptide sequences are embedded in the scaffold protein.
Preferably a scaffold protein has no post - translational modification in cells.
By ' unique ' is meant unique in the coding sequence of the scaffold protein.
One non-limiting example of a scaffold protein is the bacterial protein Thioredoxin-A.
A scaffold protein according to the present invention preferably has no protein-protein interaction domains.
Furthermore, the binding compound may be a scaffold protein having antibody-like binding characteristics.
A method according to any of claims 5 to 9, wherein said polypeptide comprises a scaffold protein.
In a further aspect the scaffold protein is selected from the group comprising,.
The inflammasome is a multimeric structure involving a cytosolic receptor, a scaffold protein - ASC - and Caspase-1.
Thus, preferably a scaffold protein according to the present invention has no glycosylation site.
Thioredoxin A ( TrxA ) is a prior art scaffold protein.
Tf acts as the scaffold protein to stabilize and increase the half-life of the peptides.
The 10Fn3 domains in a multivalent fibronectin based scaffold protein may be connected by a polypeptide linker.
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