Examples of 'sirna can' in a sentence
Meaning of "sirna can"
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How to use "sirna can" in a sentence
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sirna can
The siRNA can be administered in a single dose or in multiple doses.
It is contemplated that greater or lesser amounts of siRNA can be administered.
The siRNA can be any known to those in the art.
While in the cytoplasmic intracellular environment the siRNA can have a therapeutic effect.
The siRNA can be directed against the synthesis of one or more proteins.
The RNA duplex portion of the siRNA can be part of a hairpin structure.
The siRNA can have a stability in a standard serum assay greater than unmodified siRNA.
These data demonstrate that functional siRNA can be delivered in vivo to RPE cells.
The siRNA can also be made in vivo from a mammalian cell using a stable expression system.
Once RISC is formed the incorporated siRNA can no longer exchange with free siRNAs.
SiRNA can also be expressed from recombinant viral vectors intracellularly in vivo.
Studies have revealed that siRNA can be effective in vivo in both mammals and humans.
SiRNA can either be transfected directly or otherwise produced within a cultured cell.
The double stranded RNA siRNA can be formed by the complementary strands.
SiRNA can be used downregulate or silence the translation of a gene product of interest.
See also
Such compositions including a compound of formula I and an siRNA can further comprise a liquid medium.
The ends of the siRNA can be either blunt ends or protruding ends.
This leads to degradation of the entire mRNA ; the antisense siRNA can then be recycled.
This disadvantage of siRNA can be solved by conjugating with a carrier peptide disclosed herein.
Alternatively, the strands of the siRNA can be synthesized simultaneously.
The siRNA can efficiently mediate the down-regulation effect for some target genes in some insects.
In some embodiments, the siRNA can be expressed intracellularly.
SiRNA can then be denatured according to art-recognized methodologies.
In other embodiments, the siRNA can be outside of the liposome.
The siRNA can be a short RNA hairpin e . g.
In particular, the highly negative charged siRNA can pass cell membranes only with great difficulty.
SiRNA can be used to reduce the expression level of AceCS2.
In those embodiments, the siRNA can be complexed to the outside of the liposome.
SiRNA can be obtained by chemical synthesis or by DNA-vector based RNAi technology.
Alternatively, a DNA encoding the siRNA can be carried in a vector.
Chemically modified siRNA can also minimize the possibility of activating interferon activity in humans.
One or both strands of the siRNA can also comprise a 3 ' overhang.
SiRNA can be designed according to the technique described by Tuschl, described as follows.
EXAMPLE 8 Modified siRNA can be prepared by chemical synthesis.
A siRNA can be two RNA strands having a region of complementarity about 19 nucleotides in length.
In general, siRNA can be isolated.
The siRNA can also be engineered to contain certain " drug like " properties.
One or both strands ofthe siRNA can also comprise a 3 ' overhang.
An siRNA can contain all or a part of the sequence of SEQ ID NO, 1.
One or both strands of the siRNA can also comprise a 3 ' overhand.
Alternatively, the siRNA can be administered to a subject multiple times daily or weekly.
Thus, nucleic acids, such as siRNA can be administered to inhibit S6K1 activity.
Alternatively, the siRNA can be derivatized by standard chemical methods to introduce a thiol group.
In such embodiments, the siRNA can be complexed on the outer surface of the liposome.
Alternatively, the siRNA can be, for example, sufficiently complementary to an RNA produced by a virus.
Chemically-modified siRNA can be directly injected into the blood stream for certain applications.
For example, dsRNA or siRNA can be stabilized by including thymidine or uridine nucleotide 3 ' overhangs.
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Internet sites with siRNA selection tools
The siRNA may be chemically or enzymatically synthesized
The key is a set of molecules known as siRNA
