Examples of 'sirna molecule' in a sentence
Meaning of "sirna molecule"
sirna molecule: This phrase refers to small interfering RNA molecules, which are molecules that can inhibit the expression of specific genes in cells. These molecules play a key role in the field of molecular biology and genetics, particularly in gene regulation and RNA interference
How to use "sirna molecule" in a sentence
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sirna molecule
In a particular embodiment the cargo molecule is a siRNA molecule.
The isolated siRNA molecule of this invention may be of human origin.
Lentiviruses may be used to deliver one or more siRNA molecule to a cell.
An siRNA molecule of the invention comprises a sense region and an antisense region.
The length of one strand designates the length of an siRNA molecule.
Each siRNA molecule can turn off a specific gene inside the cell.
The method of the invention achieves translocation of the siRNA molecule into the cytosol.
The composition may include an siRNA molecule that is capable of reducing mEng expression.
The siRNA molecule may subsequently be transiently transfected into cells and exert its function.
In some embodiments, the siRNA molecule is in a carrier system.
The anti-MET therapeutic may be an siRNA molecule.
The modified siRNA molecule is less immunostimulatory than a corresponding unmodified siRNA sequence.
In one embodiment, the modified siRNA molecule is in a carrier system.
An anti-ErbB nucleic acid therapeutic may be an siRNA molecule.
Said composition may include an siRNA molecule that is capable of reducing Endoglin expression.
See also
In an exemplary embodiment, an anti-ErbB nucleic acid therapeutic is an siRNA molecule.
In another embodiment, an isolated siRNA molecule of this invention is of human origin.
The length of one strand designates the length of a double-stranded siRNA molecule.
In some embodiments, the siRNA molecule comprises at least one modified nucleotide.
In preferred embodiments, the drug carriers of the description will further comprising a siRNA molecule.
Alternatively, each type of siRNA molecule can separately be associated with a carrier.
In certain embodiments of the invention, an ANGPTL4 antagonist is a SiRNA molecule.
In another embodiment, the modified siRNA molecule further comprises a carrier system.
The use of item 19 wherein the Rspondin antagonist is an antisense molecule or siRNA molecule.
Such second siRNA molecule is preferably an siRNA molecule that targets a pro-apoptotic gene.
In one embodiment described herein, the modified siRNA molecule is in a carrier system.
The double stranded siRNA molecule of claim 6, wherein the overhang has two nucleotides.
In an exemplary embodiment, the anti-MET therapeutic is an siRNA molecule.
Preferably the siRNA molecule has the siRNA sequence as shown in the table below,.
In some instances described herein, the modified siRNA molecule comprises a hairpin loop structure.
For example, a siRNA molecule can comprise a delivery vehicle, including liposomes, for administration to a subject.
In other words, in the present invention, the siRNA molecule may chemically or enzymatically synthesized.
Preferably, the PPARGC1B antagonist is an siRNA molecule.
In another embodiment, the siRNA molecule may contain at least one modified nucleotide analogue.
A suitable inhibitor to reduce HSPC117 expression is a HSPC siRNA molecule to induce RNAi.
In one embodiment, an siRNA molecule has a two nucleotide 3 ' overhang.
The drug carrier of claim 14, further comprising a siRNA molecule.
In one embodiment, both ends of an siRNA molecule will have a 3 ' overhang.
The modified siRNA molecule or nucleic acid-lipid particle for the use of claim 13 wherein,.
For example, anti-Fas antibody ( preferably a neutralizing antibody ) may be combined with a p53 siRNA molecule.
A preferred siRNA molecule is one which acts against HER-2 mRNA.
Column 3, The number and percentage of 2 ' OMe-modified nucleotides in the siRNA molecule are provided.
The siRNA molecule may be derived from a double-stranded RNA greater than about 25 nucleotides in length.
In a particular embodiment, the siRNA molecule comprises the sequence of SEQ ID No. 1.
The siRNA molecule 9A is specific for Akt2 and serves as a negative control.
The modified siRNA molecule of claim 1, wherein,.
The siRNA molecule may comprise about 15 to about 60 nucleotides.
In some embodiments, the siRNA molecule comprises more than 20 and less than 23 bp.
The siRNA molecule may be complementary to tumor-related targets, e.g., a prostate tumor.
A modified siRNA molecule of any one of claims 1 to 6 ; or.
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The siRNA may be chemically or enzymatically synthesized
The key is a set of molecules known as siRNA
