Examples of 'sirna molecules' in a sentence
Meaning of "sirna molecules"
sirna molecules: Short for small interfering RNA, this phrase refers to a class of molecules involved in regulating gene expression by interfering with the production of specific proteins in cells
How to use "sirna molecules" in a sentence
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sirna molecules
The siRNA molecules as described herein.
Structural characteristics of effective siRNA molecules have been identified.
The siRNA molecules designed were of the short hairpin type.
Lentiviruses may be used to deliver one or more siRNA molecules to a cell.
The siRNA molecules of the invention can be incorporated into pharmaceutical compositions.
The document discloses the use of particular SiRNA molecules identified as target sequences.
The siRNA molecules can be designed using any method known in the art.
Other suitable nucleic acid molecules include siRNA molecules and antisense constructs.
The expression vectors can be introduced into target cells to thereby produce siRNA molecules.
These are important properties of siRNA molecules when applying RNAi for therapeutical purposes.
SiRNA molecules having chemical modifications that maintain or enhance activity are provided.
Identification of siRNA molecules targeting TS.
SiRNA molecules according to the above specifications are prepared essentially as described herein.
Generating siRNA Molecules.
SiRNA molecules interfere with this process.
See also
In certain embodiments, the siRNA molecules comprise a phosphodiester antisense strand.
SiRNA molecules which have chemical modifications.
In certain embodiments, the siRNA molecules comprise a phosphorothioate sense strand.
Upon transcription RNAs are likely to form double-stranded siRNA molecules.
Unprotected siRNA molecules are degraded in human plasma, with a half-live of minutes.
Hairpin structures are known in the art, for example in siRNA molecules.
Typically, synthetic siRNA molecules are chemically stabilized to prevent nuclease degradation in vivo.
In a preferred embodiment of the invention, the intact minicells carry siRNA molecules.
Accordingly, siRNA molecules are advantageously used in the methods of the present disclosure.
In certain embodiments, described herein are improved compositions for the delivery of siRNA molecules.
Accordingly, siRNA molecules are advantageously used in the methods of the present invention.
The present disclosure also features conjugates and / or complexes of siRNA molecules of the disclosure.
In other words, siRNA molecules having different sequences can be introduced simultaneously into a cell.
Delivery of ribozymes is similar to that of AS fragments and / or siRNA molecules.
Alternatively, siRNA molecules of the invention can be expressed within cells from eukaryotic promoters.
Preferred therapeutic agents are nucleic acid molecules, preferably DNA or siRNA molecules.
Once delivered, the siRNA molecules in the SNALPs silence expression of the target gene.
In addition, TACIT evaluated novel peptide carriers for the in vivo delivery of siRNA molecules.
Thus, siRNA molecules utilized by the present disclosure can be delivered into cell using retroviruses.
As shown in Figure 1B, the intact the siRNA molecules rapidly diffused into the minicells.
Various siRNA molecules developed using this technology, have proven active against different therapeutic targets.
Typically, expression vectors for transcribing siRNA molecules will have a U6 promoter.
SiRNA molecules were prepared as follows,.
In some embodiments, siRNA molecules are used as c-KIT inhibitors.
Figure 1 and Figure 2 disclose the nucleic acid sequences for several HCV-specific siRNA molecules.
Synthetic siRNA molecules also have the same effect in suppressing endogenous MMP-9 and uPAR levels.
The hairpin can be cleaved by an endoribonuclease ( e.g., Dicer ) to generate effective siRNA molecules.
In some aspects, siRNA molecules are used as c-Kit inhibitors.
The siRNA molecules according to the present invention mediate RNA interference ( “ RNAi ” ).
In certain embodiments, the siRNA molecules comprise a 3 ' hydroxyl group.
PLK-1 siRNA molecules comprising modified sense and antisense strand sequences.
These results demonstrate that the CLEC14A inhibitor siRNA molecules do, in fact, knockdown CLEC14A expression.
For instance, siRNA molecules targeting coronovirus are discussed and referenced in reference 24.
Reference 25 discloses around 20 different siRNA molecules that target influenza A virus.
SiRNA molecules also are processed by Dicer, but from a long, double-stranded RNA molecule.
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The siRNA may be chemically or enzymatically synthesized
The key is a set of molecules known as siRNA
