Examples of 't-butoxycarbonyl' in a sentence
Meaning of "t-butoxycarbonyl"
t-butoxycarbonyl (noun) - a chemical compound commonly used in organic chemistry
How to use "t-butoxycarbonyl" in a sentence
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t-butoxycarbonyl
An amino protecting group is preferably t-butoxycarbonyl or benzyloxycarbonyl.
The t-butoxycarbonyl group is removed under the reaction conditions.
Preferred amino protecting groups include t-butoxycarbonyl or benzyloxycarbonyl.
A t-butoxycarbonyl radical is particularly favorable.
Preferred amino protecting groups are carbobeozoxy and t-butoxycarbonyl.
Elimination of the t-butoxycarbonyl group may be carried out by conventional processes.
Preferred amino protecting groups are carbobenzoxy and t-butoxycarbonyl.
The t-butoxycarbonyl group is then removed with trifluoroacetic acid by standard procedures.
Particularly preferred amino-protecting group is t-butoxycarbonyl or benzyloxycarbonyl.
The elimination of the t-butoxycarbonyl group is carried out according to the usual methods.
Exemplary nitrogen protecting groups include carbobenzyloxy or t-butoxycarbonyl.
P1 is a protecting group such as t-butoxycarbonyl or other indole protecting group known in the art.
Preferred protecting groups in this instance are a benzyloxycarbonyl group or a t-butoxycarbonyl group.
A t-butoxycarbonyl group is conveniently removed using anhydrous hydrogen chloride in a solvent such as ethyl acetate.
The preferred protecting groups are t-butoxycarbonyl and methoxycarbonyl.
See also
The following is a typical method, provided the protecting group is t-butoxycarbonyl.
In case R is t-butoxycarbonyl it can be cleaved for instance in aqueous HCl or HBr.
In a preferred embodiment, said amino acid derivative is preferably t-butoxycarbonyl phenylalanine.
Preferred protecting groups are t-butoxycarbonyl also known as a BOC protecting group, and benzyloxycarbonyl.
Particularly preferred is t-butoxycarbonyl.
Among them, t-butoxycarbonyl and benzyl are preferred.
Examples of such a protective group include a t-butoxycarbonyl group and a benzoyl group.
Suitable amino protecting groups are well known in the art and include carbobenzoxy, or t-butoxycarbonyl.
Examples of such a protecting group include the t-butoxycarbonyl group and the benzoyl group.
The t-butoxycarbonyl derivative 19 is then prepared by standard methods.
The use of carbamate protecting groups, such as benzyloxycarbonyl and t-butoxycarbonyl is preferred.
Benzyloxycarbonyl, trityl, and t-butoxycarbonyl are exemplary protecting groups.
Further described is that said amino acid derivative is preferably t-butoxycarbonyl phenylalanine.
Of these groups, t-butoxycarbonyl is preferred.
Particular protecting groups that may be mentioned include acetyl, t-butoxycarbonyl and pivaloyl.
A t-butoxycarbonyl group is preferred, however.
In one embodiment, the nitrogen atom is protected with a protecting group such as a t-butoxycarbonyl group.
Among these protecting groups, t-butoxycarbonyl is particularly preferred.
Examples of suitable protecting groups for the amino function include the phthaloyl and t-butoxycarbonyl groups.
Specifically, formyl group, t-butoxycarbonyl group or the like may be mentioned.
The side chains protect the groups including t-butyl for serine and t-butoxycarbonyl for lysine.
The t-butoxycarbonyl group, which can be removed by acid hydrolysis, is used in particular.
Tf is a trifluoromethanesulfonic acid substituent ; and Boc is a t-butoxycarbonyl group.
As the alkoxycarbonyl group, a t-butoxycarbonyl group or a benzyloxycarbonyl group is, for example, preferred.
The symbol Ro represents a hydrogen atom or represents a benzyl or t-butoxycarbonyl radical.
Alternative conditions for process ( d ) include t-butoxycarbonyl group addition or removal and sulphonylation.
Preferably, the protecting group Q is a trifluoroacetyl or a t-butoxycarbonyl group.
The t-butoxycarbonyl group of compound 40a is then removed using standard deprotection reagents.
The protecting group Q is preferably a trifluoroacetate group or a t-butoxycarbonyl group.
Particularly preferred amino protecting groups such as t-butoxycarbonyl carbamate, benzyloxycarbonyl carbamate, 9-flurorenylmethyl carbamate.
In an embodiment, this protected alcohol includes as Protecting Group t-butoxycarbonyl.
Preferred amino-protecting groups are t-butoxycarbonyl and benzyloxycarbonyl.
The reaction is shown in flow diagram II wherein Boc represents t-butoxycarbonyl.
Here, formyl group, t-butoxycarbonyl group and the like may be mentioned as protecting groups.
CBZ refers to carboxybenzyl and BOC refers to t-butoxycarbonyl as protective groups.
