Examples of 'thymidylate synthase' in a sentence
Meaning of "thymidylate synthase"
thymidylate synthase ~ a key enzyme involved in DNA synthesis and repair processes in biological systems
How to use "thymidylate synthase" in a sentence
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thymidylate synthase
It works through noncompetitive inhibition of thymidylate synthase.
Comprising a thymidylate synthase gene inactivated by gene disruption.
The conversion is catalyzed by thymidylate synthase.
Thymidylate synthase catalyzes the intracellular conversion of deoxyuridylate to deoxy thymidylate.
Nolatrexed is a thymidylate synthase inhibitor.
This methyl group is added on by an enzyme called thymidylate synthase.
Antitumor agents that target thymidylate synthase are important drugs in the chemotherapy of cancer.
The synthesis of substrates for enzymes like thymidylate synthase.
Several examples of substrates for thymidylate synthase are provided in the specifications of this application.
A valid target for an antifolate is the enzyme thymidylate synthase.
RNAi molecule targeting thymidylate synthase and application thereof.
Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.
Thymidylate synthase X is a flavoprotein discovered recently.
Several examples of substrates for thymidylate synthase are provided herein.
The disclosed compounds are reported to possess inhibitory activity against thymidylate synthase.
See also
The repeat units constituting the promoter of the thymidylate synthase gene are not completely identical.
Preferred compounds of the invention are active in inhibiting the enzyme thymidylate synthase.
In addition, they unravelled a role for thymidylate synthase enzymes in tuberculosis pathogenesis.
Preferably the target nucleic acid is the mRNA encoding thymidylate synthase.
That is, the expression level of thymidylate synthase is inversely correlated to the responsiveness.
Preferred compounds of the present invention are capable of inhibiting the enzyme thymidylate synthase.
Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.
The genotype relates to the responsiveness of a subject towards an antitumor agent targeting thymidylate synthase.
On the other hand, the reaction catalyzed by thymidylate synthase requires reduction of dihydrofolate.
Figure 8 shows reaction products of prodrug compounds with the enzyme thymidylate synthase.
Pyrimidine antagonists interfere with thymidylate synthase to reduce thymidine production and are S-phase specific.
A particularly preferred gene for the methods of the invention is the thymidylate synthase gene.
Technology Review Thymidylate synthase ( TS ) is an essential enzyme for DNA synthesis.
Antifolate agents work by inhibiting the action of key enzymes thymidylate synthase and dihydrofolate reductase.
Thymidylate synthase is the direct target enzyme of 5-FU-type antitumor agents.
The purported mechanism of interaction of IV is enhanced thymidylate synthase inhibition.
Lactis thymidylate synthase gene (thyA) has been cloned by Ross et al.
Technical Field The present invention relates to the genotyping of the thymidylate synthase gene.
Thymidylate synthase is an important target of not only 5-FU, but also other antitumor agents.
Industrial Applicability An oligonucleotide for genotyping the thymidylate synthase gene is provided.
However, polyglutamated methotrexate inhibits thymidylate synthase and dihydrofolate reductase, potentially increasing cytotoxicity of 5-FU.
Of these, preferred antisense oligonucleotides are those which inhibit thymidylate synthase expression.
Thymidylate synthase (TS) activity measurements.
The synthesis of dTMP starting from dUMP is catalyzed by thymidylate synthase ( thyA gene ).
For example, thymidylate synthase from yeast could be substituted for that of E. coli in Figure 4.
The researchers have discovered several peptides that inhibit thymidylate synthase by modulating protein-protein interactions.
The human thymidine synthase can be purified from E. coli containing the expressed human thymidylate synthase.
Raltitrexed is a selective inhibitor of thymidylate synthase as described, e . g ., in Kamen, supra.
That is, Methotrexate is an antitumor agent that indirectly inhibits thymidylate synthase.
Thymidylate synthase is a target for chemotherapeutic drugs, most commonly the antifolate agent 5-fluorouracil ( 5-FU ).
This invention relates to antisense oligodeoxynucleotides targeted to sequences in thymidylate synthase ( TS ) mRNA.
The conversion is catalysed by thymidylate synthase ( TS ).
These enzymes include GAR transformylase, AICAR transformylase, dihydrofolate reductase and thymidylate synthase.
With cells with a raised level of thymidylate synthase ( TS ).
The use of claim 42 for the inhibtion of the enzyme thymidylate synthase.
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