Examples of 'thymidine kinase' in a sentence
Meaning of "thymidine kinase"
Thymidine kinase is an enzyme involved in DNA replication and cell division. It catalyzes the transfer of phosphate groups to thymidine, a building block of DNA, converting it into a form that is used to synthesize new DNA strands. Thymidine kinase plays a crucial role in cell proliferation and is often used as a biomarker in medical diagnostics and cancer research
How to use "thymidine kinase" in a sentence
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thymidine kinase
Thymidine kinase is not present in fungi.
The cytotoxic gene product may be thymidine kinase.
Antibodies against thymidine kinase are available for immunohistochemical detection.
Imaging infection with compounds that bind to thymidine kinase.
Thymidine kinase diagnostic assay for gene therapy applications.
The cytotoxic gene is the cDNA for thymidine kinase.
Herpes thymidine kinase is an example.
The cells then start to produce the thymidine kinase enzyme.
Cellular thymidine kinase converts zidovudine into zidovudine monophosphate.
Other markers can include thymidine kinase and the like.
The thymidine kinase gene.
In swinepox preferred insertion sites include the thymidine kinase gene region.
Thymidine kinase is required for the action of many antiviral drugs.
Activation of ganciclovir by viral thymidine kinase is currently being evaluated in clinical trials.
Thymidine kinase has been determined in tissue samples after extraction of the tissue.
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Direct determination of the thymidine kinase protein by immunoassay has also been used.
Thymidine kinase mutants of the present invention may be constructed using a variety of techniques.
The ganciclovir is phosphorylated by the thymidine kinase of herpes simplex virus to be activated.
In which the lacZ gene is replaced with a selectable gene for thymidine kinase.
Thymidine kinase levels in serum or plasma have been mostly measured using enzyme activity assays.
Gancyclovir treatment selectively kills cells expressing thymidine kinase at high expression levels.
Thymidine kinase converts nucleoside analogs or prodrugs into potent cytotoxic agents in dividing cells.
A representative example of such a suicide protein is thymidine kinase of the herpes simplex virus.
The thymidine kinase gene is located within the UI region of the genome.
The suicide gene used is the thymidine kinase gene of the herpes simplex virus.
Examples of therapeutic genes are tumor suppressor genes and the suicide gene thymidine kinase.
Diphtheria toxin or the thymidine kinase of Herpes simplex virus are exemplary lethal genes.
Several studies verify the close connection between prognosis and thymidine kinase activity in myelomas.
As a result, thymidine kinase is expressed in the cancer tumour.
The genes for these tumor markers may be used as promoter genes for thymidine kinase.
The vector includes the Herpes Simplex thymidine kinase promoter and the selectable neomycin gene.
In one preferred embodiment said cytotoxic protein is HSV thymidine kinase.
These include DNA polymerase and thymidine kinase which are needed for DNA replication.
HAT sensitivity can be similarly produced using bromodeoxyuridine to induce thymidine kinase deficiency.
Therefore, a gene for thymidine kinase must be incorporated in the genome.
Prototypical vaccinia vectors contain transgenes inserted into the viral thymidine kinase gene vÃa homologous recombination.
Specifically, thymidine kinase may be transduced into herpes simplex virus.
The attenuated HSV may contain the thymidine kinase gene.
However, the ability of thymidine kinase to phosphorylate potentially useful nucleoside analog prodrugs is limited.
The attenuated HSV of the present invention may contain the thymidine kinase gene.
For example, the gene thymidine kinase when expressed converts the drug gancyclovir into a toxic product.
Such a peptide complex is preferred wherein the said cytotoxic protein is HSV thymidine kinase.
Composition comprising interleukin-2 and thymidine kinase for the treatment of tumors.
Subsequently, the drug may be phosphorylated into its active form by a thymidine kinase.
A vaccine as claimed in claim 2, wherein the thymidine kinase is of vaccinia virus origin.
The available anti-herpes chemotherapy is efficient but depends on a functional viral thymidine kinase.
For example, thymidine kinase may be incorporated into a pseudovirus or VIP.
In another embodiment, the cytotoxic gene product is thymidine kinase.
The thymidine kinase gene will typically be that derived from the Herpes Simplex virus ( HSVtk ).
In swinepox, insertion sites include the thymidine kinase gene region.
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Examples of using Thymidine
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It phosphorylates thymidine to create thymidine monophosphate dTMP
Cell proliferation is determined by incorporation of tritiated thymidine
The thymidine can be bound to phosphate groups
Examples of using Kinase
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Creatine kinase can be checked if myalgias develop
Blood tests show elevated creatine kinase
Elevation of creatine kinase in blood is indicative of myositis
