Examples of 'topoisomerase' in a sentence
Meaning of "topoisomerase"
a type of enzyme that controls the winding and unwinding of DNA strands during cell replication
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- Any of several enzymes that affect the topology of DNA, especially ones that relax supercoiling.
How to use "topoisomerase" in a sentence
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topoisomerase
The chemotherapeutic agent may be a topoisomerase inhibitor.
Topoisomerase inhibitors can also function as antibacterial agents.
A currently preferred topoisomerase inhibitor is irinotecan.
Topoisomerase inhibitors represent a further class of oncolytic agents.
It is preferable that topoisomerase inhibitor is etoposide.
Topoisomerase inhibitors represent a further type of chemotherapeutic agents.
Combination therapy with a topoisomerase inhibitor.
Many topoisomerase inhibitors comprise one or more chiral centers.
Quinolones are so called topoisomerase poisons.
Topoisomerase activity can be determined using any method or assay.
An example of such a protein is topoisomerase.
Irinotecan is in topoisomerase inhibitor family of medication.
Camptothecin is an anticancer drug that may function as a topoisomerase inhibitor.
Topoisomerase inhibitors are often divided according to which type of enzyme it inhibits.
Etoposide is an example of a topoisomerase inhibitor.
See also
It a topoisomerase inhibitor and is considered an ideal antiglioma drug for local delivery.
This domain also possesses a sequence independent topoisomerase activity.
Within the prodrug a topoisomerase inhibitor is releasably attached to a polyethylene glycol moiety.
One category of drugs used for cancer therapy is topoisomerase inhibitors.
Topoisomerase IIa immunoreactivity increased with proliferation and malignancy grade in oligodendrocytic tumors.
The liposomes of the invention include a topoisomerase inhibitor entrapped in the liposome.
Additional topoisomerase targeting agents with anticancer properties include those described by LaVoie et al.
The stress caused by this effect is in part aided by the topoisomerase enzymes.
Lipoic acid is also a topoisomerase inhibitor and an oxidative agent for glycolytic therapy.
These effects can be attributed to inhibition of topoisomerase II.
Hybrid topoisomerases of the present invention can be used to assay and monitor topoisomerase activity.
It works in part by blocking the function of topoisomerase II.
Topoisomerase II inhibitors are described in various scientific publications.
Relaxation was found to be unrelated to the activity of topoisomerase IV.
Examples of topoisomerase II inhibitors include etoposide and teniposide.
Such a cleavage mechanism is characteristic of a type II topoisomerase.
Topoisomerase II inhibitors can increase the risk of a second cancer.
Etoposide appears to function as a topoisomerase II poison.
Topoisomerase IIA plays an essential role in resolving these topological problems.
This analog also possessed exceptional potency as a topoisomerase II poison.
Drugs that target topoisomerase II can be divided into two groups.
This analogues also possessed exceptional potency as a topoisomerase II poison.
DNA topoisomerase II is an enzyme which is essential to the life of eukaryotic cells.
Mammalian cells contain type II topoisomerase similar to that contained in bacteria.
Topoisomerase II is transiently expressed only during division phase in normal cells.
Those various compounds act by inhibiting the catalytic activity of topoisomerase II.
Examples of topoisomerase II inhibitors include epipodophyllotoxins such as etoposide and teniposide.
These various compounds act by inhibiting the catalytic activity of topoisomerase II.
Specific enzymes of the topoisomerase family are responsible for disentangling DNA.
Gemifloxacin is highly selective for bacterial rather than human topoisomerase II.
Topoisomerase enzymes can knot DNA and thus change its topology.
The prodrugs may be alkylating agents having topoisomerase II inhibiting activities.
Such modulation of topoisomerase activity can also be monitored by assaying DNA topology.
Etoposide is a chemotherapeutic drug derived from podophyllotoxin and acts as an inhibitor of topoisomerase II.
DNA topoisomerase are a family of enzymes that are involved in DNA replication and metabolism.
