Examples of 'topoisomerases' in a sentence
Meaning of "topoisomerases"
Topoisomerase is a type of enzyme that controls the overwinding or underwinding of DNA strands during processes such as transcription and replication
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- plural of topoisomerase
How to use "topoisomerases" in a sentence
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topoisomerases
There are two major classes of mammalian topoisomerases.
Topoisomerases also come in handy when you are sick.
Wang was the first discoverer of topoisomerases.
Topoisomerases are enzymes with both nuclease and ligase activity.
Irinotecan inhibits the activity of topoisomerases.
Topoisomerases are essential enzymes to the cellular development and are overexpressed in cancer cells.
The catenated circles require the action of topoisomerases to separate the circles.
Topoisomerases also play critical roles in maintaining chromosome and nuclear structure.
These derivatives additionally have action on the topoisomerases which they inhibit.
Hybrid topoisomerases of the present invention can be used to assay and monitor topoisomerase activity.
We show that single molecule experiments allow detailed analysis of the kinetic cycle of topoisomerases.
Topoisomerases are enzymes that regulate the unwinding of DNA.
DNA topoisomers can be interchanged by enzymes called topoisomerases.
Type II topoisomerases are the target of a number of antibacterial agents.
It was found that ATA is a strong inhibitor of topoisomerases and other nucleases.
See also
Topoisomerases are isomerase enzymes that act on the topology of DNA.
It has a novel mechanism of action which involves inhibition of bacterial type II topoisomerases.
Topoisomerases are essential enzymes that maintain the topology of DNA.
In contrast eukaryotic type II topoisomerases are homodimers.
Topoisomerases regulate the winding and unwinding of DNA strands.
Drugs which target topoisomerases such as etoposide ;.
Topoisomerases catalyze the introduction and relaxation of superhelicity in DNA.
However, alternative compounds that inhibit bacterial topoisomerases are required.
Topoisomerases are enzymes that are capable of altering DNA topology in eukaryotic cells.
Therefore, cytotoxicity and inhibitory activity on human topoisomerases i and ii tests were performed.
Bacterial type II topoisomerases form a heterotetrameric complex composed of two subunits.
In another aspect, the present invention provides methods of assaying the activity of topoisomerases.
Topoisomerases can remove negative or positive supercoils from DNA or can introduce negative supercoils.
In this study, we investigated the topoisomerases iii from trypanosoma cruzi tctopo and tctopo.
Topoisomerases reduce supercoiling of DNA in the cell.
The task of un-knotting topologically linked strands of DNA falls to enzymes termed topoisomerases.
DNA topoisomerases are enzymes present in all cells that catalyze topological changes in DNA.
Topoisomerasetargeting drugs appear to interfere with this breakage-reunion reaction of DNA topoisomerases.
Type II topoisomerases catalyze DNA strand passage through transient double strand breaks in the DNA.
In nature, most DNA has slight negative supercoiling that is introduced by enzymes called topoisomerases.
Detailed Description DNA topoisomerases are nuclear enzymes responsible for modifying the topological state of DNA.
Research Project, Characterization of the interaction of autoantibodies anti-DNA topoisomerases with fibroblasts in systemic sclerosis.
RNase HI and type LA DNA topoisomerases play a leading role in preventing unregulated replication.
Further mechanistic studies indicate that beta-carboline derivatives inhibit DNA topoisomerases and interfere with DNA synthesis . ".
In recent years, topoisomerases have become popular targets for cancer chemotherapy treatments.
Exemplary enzymes include ligases, polymerases, and topoisomerases.
As inhibitor of topoisomerases II mention can be made of etoposide, mitopodoside, teniposide.
DNA gyrase ( gyrase ) and topoisomerase IV ( topo IV ) are both bacterial type II topoisomerases.
By way of background, topoisomerases are enzymes which control the topological state of DNA.
Topoisomerases are enzymes that catalyze the relaxation of negatively supercoiled deoxyribonucleic acid ( DNA ).
In addition, type IIA topoisomerases are able to simplify DNA topology.
Topoisomerases wind and unwind DNA during replication ( when a cell is copying its DNA prior to division ).
There are two classes of topoisomerases in eukaryotic cells, type I and type II.
Topoisomerases are required for many processes involving DNA, such as DNA replication and transcription.
Abstract, The type 2 DNA topoisomerases are universal proteins essential for cell survival.
