Examples of 'ubiquitination' in a sentence
Meaning of "ubiquitination"
ubiquitination (noun): A biochemical process in which a small protein called ubiquitin is attached to other proteins to mark them for degradation or regulate their functions. Ubiquitination plays a crucial role in cellular processes such as protein turnover, signal transduction, and DNA repair. In scientific contexts, 'ubiquitination' refers to this specific biological mechanism
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- The modification of a protein by the covalent attachment of one or more ubiquitin molecules
How to use "ubiquitination" in a sentence
Basic
Advanced
ubiquitination
This dual regulation by phosphorylation or ubiquitination is unprecedented.
Ubiquitination involves the sequential action of three enzymes.
Measuring the amount or rate of ubiquitination.
Ubiquitination requires the action of three different enzymes.
Phosphorylation targets IkBs for ubiquitination and degradation.
Ubiquitination refers to a modification of proteins by conjugation to ubiquitin molecules.
Also provided herein is a method of identifying a ubiquitination modulator.
Ubiquitination in turn targets the substrate protein for degradation.
This is a markedly different mechanism to the usual process of ubiquitination.
It is thought that ubiquitination signals degradation within the cell.
Sumoylation of target proteins involves a reaction mechanistically similar to ubiquitination.
The ubiquitination of these proteins is mediated by a cascade of enzymatic activity.
In particular they looked at enzymes involved in the ubiquitination process.
The ubiquitination of terminally misfolded proteins is caused by a cascade of enzymatic reactions.
Phosphorylation targets IκBs for subsequent ubiquitination and degradation.
See also
Ubiquitination and SUMOylation.
A polypeptide can be branched following an ubiquitination or be cyclic with or without branching.
This enzyme functions in a cascade of reactions that lead to protein ubiquitination.
Ubiquitination is an important process that helps regulate several key cellular functions.
Poxvirus control of ubiquitination.
However, histone ubiquitination has received little attention.
The invention is also directed to assays for identifying modulators of ubiquitination.
Polypeptide may be branched following ubiquitination or may be cyclic with or without branching.
Other posttranslational modifications at lysine residues include acetylation and ubiquitination.
Protein extracts were prepared and used for ubiquitination reactions as described above.
This protein plays an important role in protein degradation and protein ubiquitination.
An investigation into ubiquitination of AGO was less conclusive.
There is no discussion about inhibition of the proteasome by blocking ubiquitination at all.
GABAB shows a high constitutive ubiquitination and internalization level.
One way that cells regulate the destruction of proteins is via ubiquitination.
This allows for Parkin mediated ubiquitination on other proteins.
These data suggest that the defect in cyclin proteolysis is due to defective ubiquitination.
In a further embodiment of the invention ubiquitination is detected by Western blot analysis.
This invention is directed to assays for measuring the activity of ubiquitination enzymes.
Regulation of MHC class II ubiquitination in antigen presenting cells.
Each fraction was assayed for its ability to support the ubiquitination of IkBa.
A method of assaying ubiquitination enzyme activity comprising,.
Embodiments of the present invention involve binding ubiquitin to a ubiquitination substrate protein.
That catalyzes the ubiquitination of histones in vitro;.
The late domain is thought to represent a docking site for the ubiquitination machinery.
In a preferred embodiment, the ubiquitination substrate protein is ubiquitin.
Additional experiments reveal that this IkBa kinase can be activated by a prior ubiquitination event.
A method of identifying a ubiquitination modulator comprising,.
PHF can also be modified by glycosylation and ubiquitination.
Such ubiquitination results in the release and activation of NF-kB.
The resin was discarded and the unbound material tested in the ubiquitination assay described above.
Ubiquitination is one of the most important post-translational modifications.
SUMOylation is directed by an enzymatic cascade analogous to that involved in ubiquitination.
This leads to ubiquitination of HIF-alpha and subsequent degradation.
Exemplary methods for assessing SPOP substrate ubiquitination are described herein.
