Examples of 'ubiquitin ligase' in a sentence
Meaning of "ubiquitin ligase"
This term refers to a group of enzymes that help regulate protein levels within cells by attaching ubiquitin molecules to specific proteins. Ubiquitin ligases play a crucial role in targeting proteins for degradation or modifying their function, influencing various cellular processes
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- A protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, promoting protein ubiquitination and degradation.
How to use "ubiquitin ligase" in a sentence
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ubiquitin ligase
Parkin is one of a family of ubiquitin ligase enzymes.
Ubiquitin ligase inhibitors are being developed forthe treatment of cancer.
It also possess ubiquitin ligase activity.
Ubiquitin ligase is a protein which covalently attaches ubiquitin to a lysine residue on a target protein.
A modulator that specifically affects ubiquitin ligase activity is a ubiquitin ligase modulator.
This interaction is crucial for the recruitment of substrates to the ubiquitin ligase complex.
Itch is an ubiquitin ligase involved in protein recognition and degradation by the proteasome.
The present invention provides methods for assaying ubiquitin ligase activity.
A novel ubiquitin ligase is deficient in Fanconi anemia.
This method may further involve combining a candidate ubiquitin ligase modulator in the combining step.
ITCH is a ubiquitin ligase involved in various cellular processes including endocytosis.
This conjugation, called neddylation, is required for optimal ubiquitin ligase activity.
The parkin protein functions as a ubiquitin ligase that targets proteins for degradation.
In a preferred embodiment, no specific target protein is used to measure ubiquitin ligase activity.
Screening of the mutants is done using ubiquitin ligase activity assays of the present invention.
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Accordingly, the present invention provides methods and compositions for assaying ubiquitin ligase activity.
A method of assaying ubiquitin ligase activity comprising,.
Such an identified modulator can be a substance that interferes with CUL4A ubiquitin ligase activity.
The test substance that modulates CUL4A ubiquitin ligase activity can be any suitable substance.
The E3 ubiquitin ligase is able to recognize misfolded proteins and ubiquinate them.
Figures 5A and 5B shows the results from two identified modulators of ubiquitin ligase activity.
Figure 3B shows relative ubiquitin ligase activity using varying amounts of ubiquitin and E3.
M syndrome is an autosomal-recessive growth retardation disorder associated with mutations of the Cullin7 E3 ubiquitin ligase.
In a preferred embodiment, the ubiquitin ligase is an E3 ubiquitin ligase, defined below.
The method of claim 1 or claim 2, further comprising in step a, combining a candidate ubiquitin ligase modulator.
The scientists identified UBE2L3, an ubiquitin ligase located in a CeD-associated region.
E3 ubiquitin ligase activity of the trifunctional ARD1 ADP-ribosylation factor domain protein 1.
Parkin is a cytosolic E3 ubiquitin ligase.
The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.
It is further demonstrated that Trabid has E3 ubiquitin ligase activity.
Neuralized ( Neur ) is an E3 ubiquitin ligase conserved from nematodes to mammals.
We also disclose a further Trabid activity, E3 ubiquitin ligase activity.
WWP1 is an E3 ubiquitin ligase that triggers polyubiquitination and degradation of TGF-β type I receptor.
To increase such affinity, proteins such as the SUMO-dependent ubiquitin ligase RNF4 contain 4 SIM domains.
MARCH1 is an E3 ubiquitin ligase which targets MHC-II and re-localises the complex into recycling endosomes.
Background UBE3A is maternally expressed in neurons and encodes an E3 ubiquitin ligase named E6-AP.
They identified UBE2L3, a ubiquitin ligase located in a CD-associated region.
CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions.
The E3 ubiquitin ligase MDM2 is a negative regulator of the p53 tumor suppressor protein.
Angelman syndrome is caused by a disruption of UBE3A, which encodes a ubiquitin ligase ( E3 ) enzyme termed E6-AP.
One suitable E3 ubiquitin ligase is the von Hippel-Lindau tumour suppressor ( VHL ).
The present invention provides the use of Parkin protein ( Parkin ) as ubiquitin ligase ( E3 ).
CUL4B-based E3 ubiquitin ligase complexes often demonstrate overlapping activity with CUL4A-based complexes.
At steady-state, antigen presenting cells express the ubiquitin ligase E3 MARCH1.
The transmembrane E3 ubiquitin ligase is selected from the group consisting of ZNRF3 and RNF43 ; and.
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Examples of using Ligase
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The ligase may also be a thermostable ligase
Parkin is one of a family of ubiquitin ligase enzymes
Ligase is added and the mixture incubated
Examples of using Ubiquitin
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Function of ubiquitin dependent proteolysis during spermatogenesis
The label consists of a molecule called ubiquitin
The ubiquitin intron is shown in lowercase letters
