Examples of 'variable domain' in a sentence
Meaning of "variable domain"
Variable domain commonly refers to the set of values that a variable can take within a specific context. In mathematics and computer science, it represents the range of possible input values for a given function or program
How to use "variable domain" in a sentence
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variable domain
E light chain variable domain nucleotide sequence.
The antibody polypeptides comprise a variable domain.
E heavy chain variable domain nucleotide sequence.
The mutations may be made in a variable domain.
Variable domain framework residues have little or no direct contribution.
Exemplary binding domains include an antibody variable domain.
An immunoglobulin chain comprises a variable domain and optionally a constant domain.
A light chain comprises a constant domain and a variable domain.
The variable domain determines recognition and specificity to a particular antigen.
The factory default for the variable domain name is.
The variable domain of any heavy chain is composed of a single immunoglobulin domain.
The present invention relates to a modified immunoglobulin variable domain.
The pH of the immunoglobulin single variable domain solution can be decreased.
Such residues are typically derived from a heavy chain variable domain.
The individual variable domain proteins can be expressed separately during cloning.
See also
Humanized antibody variable domain.
In the heavy chain variable domain there is an unusual feature in the framework region.
The size of a linker in one embodiment is equivalent to a single variable domain.
The basic structure of the antibody variable domain is strongly conserved.
A heavy chain refers to any polypeptide that a heavy chain variable domain.
Regions between CDRs in the variable domain of an immunoglobulin are known as framework regions.
The expression system may involve display of the variable domain.
The immunoglobulin single variable domain may also be transferred into physiological saline.
The art knows many derivatives and analogues of variable domain antibodies.
List the human antibody variable domain sequences and compare for homology.
The multivalent antibody herein four light chain variable domain polypeptides.
In a particular embodiment the variable domain of a heavy chain antibody is derived from camelids.
The given amino acid sequences start at position one of the variable domain.
Each chain is in turn comprised of a variable domain and a constant domain.
Such variable domain sequences may then be combined with a desired human constant domain.
The minimum such region is typically a variable domain or a genetically engineered variant thereof.
A light chain also consists of one constant domain and one variable domain.
Defined a numbering system for variable domain sequences that is applicable to any antibody.
The invention encompasses specific binding reagents composed of a plurality of variable domain proteins.
Each heavy chain has at one end a variable domain followed by a number of constant domains.
Some of these may be used for immobilising single or multiple variable domain proteins.
In one embodiment the variable domain pair which form a binding site is a cognate pair.
This is done independently for both the heavy and light chain variable domain sequences.
The variable domain frameworks and constant domains were derived from human antibody sequences.
Both heavy and light chains comprise a variable domain and a constant part.
The single variable domain can be derived from an antibody directed against the antigen.
Included in this arrangement would be the proximal orientation of information encoding the variable domain.
The human variable domain which is most homologous is chosen as the framework for humanisation.
The purification tag can be introduced into the variable domain in several different ways.
These species are namely known to produce high affinity antibodies of only a single variable domain.
Single domain antibodies have a single variable domain that is capable of efficiently binding antigen.
The antibody polypeptides disclosed herein may be a domain antibody containing a single variable domain.
The light chain variable domain is aligned with the variable domain of the heavy chain.
A common denominator of such specific binding bodies is the presence of a heavy chain variable domain.
In one embodiment the antibody comprises a variable domain pair forming a binding domain is a cognate pair.
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